A look to the future: cyclodextrins and cyclodextrin-based drug delivery to the retina

Expert Opinion on Drug Delivery, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Retinal diseases are a leading cause of vision loss, affecting millions people worldwide. Current treatment options based on invasive methods such as intravitreal injections. Therefore, there is need for alternative therapeutic strategies that both effective and more patient-friendly. Topical drug delivery has gained attention preferred noninvasive approach, although it hindered by several ocular barriers. Cyclodextrin (CD)-based nanoparticles have emerged promising strategy to overcome these limitations enhancing permeability in the posterior segment eye. This review discusses potential CDs enabling pharmaceutical excipients, their role improving bioavailability, provides examples CD-based eye drop formulations currently under development or undergoing clinical trials. Also, active agents ophthalmology discussed. nanoparticle drops present solution shown success. approved excipients can act ingredients inherent retinal diseases. Future innovations hybrid systems integration novel compounds could provide efficient targeted

Язык: Английский

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The Impact of NF-κB on Inflammatory and Angiogenic Processes in Age-Related Macular Degeneration

Experimental Eye Research, Год журнала: 2024, Номер 248, С. 110111 - 110111

Опубликована: Сен. 24, 2024

Язык: Английский

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Nanosystems - Combination products

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 141 - 163

Опубликована: Окт. 1, 2024

Язык: Английский

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