Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach

Experimental & Molecular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Abstract Chronic neuropathic pain is a debilitating neuroplastic disorder that notably impacts the quality of life millions people worldwide. This complex condition, encompassing various manifestations, such as sciatica, diabetic neuropathy and postherpetic neuralgia, arises from nerve damage or malfunctions in processing pathways involves biological, physiological psychological processes. Maladaptive neuroplasticity, known central sensitization, plays critical role persistence chronic pain. Current treatments for include pharmacological interventions (for example, antidepressants anticonvulsants), invasive procedures deep brain stimulation) physical therapies. However, these approaches often have limitations potential side effects. In light challenges, interest noninvasive neuromodulation techniques alternatives complementary increasing. These methods aim to induce analgesia while reversing maladaptive plastic changes, offering advantages over conventional practices methods. Recent technological advancements spurred exploration therapies, repetitive transcranial magnetic stimulation, direct current stimulation ultrasound well innovative transformations into at both preclinical clinical levels. Here this review aims critically examine mechanisms neuroplasticity evaluate efficacy relief. By focusing on optimizing techniques, we can better assess their short-term long-term effects, refine treatment variables ultimately improve management.

Язык: Английский

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Feasibility of trancutaneous auricular vagus nerve stimulation in Black and Hispanic/Latino people with peripheral neuropathy

Frontiers in Pain Research, Год журнала: 2025, Номер 5

Опубликована: Янв. 17, 2025

Peripheral neuropathy (PN) is the most common neurodegenerative disorder, and primary causes are chemotherapy-induced peripheral (CIPN) diabetic (DN). Transcutaneous auricular vagus nerve stimulation (taVNS) a promising non-pharmacological non-invasive intervention that targets key pathways involved with PN. However, research needed to determine feasibility, acceptability, effects of taVNS in people It also critical this on include perspectives Black Hispanic/Latino patients, who often underrepresented research. This was comprised two consecutive studies: survey pilot randomized sham-controlled trial (RCT). The assessed symptom burden, management strategies, interest among CIPN patients. RCT evaluated preliminary patients or neuropathy. Participants were recruited from University Miami medical system, culturally sensitive approaches enhance minority participation. included 62 respondents, 78% Hispanic/Latino, revealing high burden significant (82% expressed moderate interest). enrolled 28 participants, achieving 42% recruitment rate 86% retention. well tolerated, no adverse effects. Preliminary data indicated decrease neuropathic symptoms an increased heart variability (HRV) during active taVNS, suggesting autonomic modulation. Tingling sensation pain decreased by median values 2.0 1.5, respectively. Additionally, for standard deviation RR interval 34.9 (CI = 21.6-44.8) at baseline 44.8 26.5-50.3) intervention. Exit interviews highlighted positive participant experiences identified potential barriers, such as protocol length distrust findings underscore need novel treatments demonstrate feasibility conducting historically populations. High successful retention rates suggest can participation clinical trials. These will be used develop large efficacy repeated diverse cohort. https://clinicaltrials.gov, identifier (NCT05896202).

Язык: Английский

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Der Vagusnerv und die Stimulation seines aurikulären Astes in der Schmerztherapie

Schmerz Nachrichten, Год журнала: 2025, Номер 25(1), С. 55 - 66

Опубликована: Апрель 1, 2025

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Relieving dyspnoea through the brain

European Respiratory Journal, Год журнала: 2024, Номер 64(6), С. 2401828 - 2401828

Опубликована: Дек. 1, 2024

ExtractDyspnoea is defined as a symptom conveying an upsetting or distressing experience of breathing awareness, which can vary in quality (e.g. air hunger, increased work/effort breathing, chest tightness) and intensity, leading to subsequent physiological behavioural responses [1–3]. It the cardinal widespread pulmonary cardiac diseases, such asthma [4], COPD [5] heart failure [6], but also prevalent various other common conditions, including neuromuscular cancer mental disorders, anxiety, panic functional somatic syndromes [3, 7–10].Shareable abstract @ERSpublicationsDyspnoea under-recognised under-treated major health problem currently available treatment options are limited. Several promising non-pharmacological treatments have recently been developed that may relieve dyspnoea by treating brain. https://bit.ly/3XQMH7YShare

Язык: Английский

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Neuromodulação não-invasiva

Revista Brasileira de Pesquisa em Saúde/Brazilian Journal of Health Research, Год журнала: 2024, Номер 26(1), С. e46477 - e46477

Опубликована: Окт. 31, 2024

Introdução: A neuromodulação não invasiva (NmNI) abrange um conjunto de técnicas que modulam a atividade neuronal sem necessidade cirurgia ou implantes. O interesse nessas vem crescendo, especialmente em relação à sua aplicabilidade e translação resultados protocolos pesquisa para prática clínica. Com isso, surgem questões sobre segurança dos procedimentos, seus efeitos fisiológicos os mecanismos ação cerebral. Objetivo: Discutir aplicabilidade, efeitos, as barreiras acesso ao tratamento explorar direções futuras Métodos: Trata-se uma revisão narrativa da literatura, incluindo ensaios clínicos, revisões sistemáticas, meta-análises artigos opinião, com pesquisas nas bases dados PubMed, Scopus, Google Scholar Web of Science. Discussão: As NmNI tendem ser menos invasivas, mais seguras acessíveis do intervenções neurocirúrgicas, apresentando-se como alternativa às estratégias farmacológicas, poucos colaterais. Aspectos portabilidade, escalabilidade custo-benefício, além potencial uso doméstico, devem considerados. Embora amplamente usadas reabilitação, ainda é necessário padronizar parâmetros aplicação ampliar o toda população. Conclusão: focar na padronização protocolos, no aprofundamento das neurobiológicas expansão novos contextos clínicos. Uma vez limitado por financeiras, geográficas educacionais, torna-se essencial criação políticas garantam inclusão saúde pública.

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Neurocardiology: Major mechanisms and effects

Journal of Electrocardiology, Год журнала: 2024, Номер 88, С. 153836 - 153836

Опубликована: Ноя. 22, 2024

Язык: Английский

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