Psychosomatic Medicine, Год журнала: 2024, Номер 86(5), С. 360 - 365

Опубликована: Май 8, 2024

ABSTRACT The “geroscience hypothesis” posits that slowing the physiological processes of aging would lead to delayed disease onset and longer healthspan lifespan. This shift from a focus on solely treating existing process is toward prevention, including risk factors found in social environment. Although geroscience traditionally has focused molecular cellular drivers biological aging, more fundamental causes may be exposome—the complex array human environmental exposures shape health disease. exposome interact with accelerate biology. In this commentary, we review potential these insights emerging field translational geroscience. articles special issue highlight how stress determinants are associated biomarkers such as inflammation, epigenetic clocks, telomeres, spotlight promising interventions mitigate stress-related inflammation. For incorporate into its agenda, studies needed elucidate quantify effects consider intervention targets. life course perspective allows us measure both biology over time sensitive periods development major transitions. addition, given rapid changes measurement biology, which include machine learning techniques, multisystem phenotypes being developed better reflect whole body replacing reliance single system biomarkers. expanded integrated geroscience, strategies targeting hold promise for achieving equity extending healthy longevity.

Язык: Английский