Current basic research in normothermic machine perfusion
European Surgical Research,
Год журнала:
2024,
Номер
65(1), С. 137 - 145
Опубликована: Окт. 29, 2024
Background:
Normothermic
machine
perfusion
(NMP)
is
gradually
being
introduced
into
clinical
transplantation
to
improve
the
quality
of
organs
and
increase
utilisation.
This
review
details
current
understanding
underlying
mechanistic
effects
NMP
in
heart,
lung,
liver,
kidney.
It
also
considers
recent
advancements
extend
interval
these
use
introduce
novel
therapeutic
interventions,
with
a
focus
on
organ
modulation.
Summary:
The
re-establishment
circulation
during
leads
upregulation
inflammatory
immune
mediators,
similar
an
ischaemia-reperfusion
injury
response.
level
determined
by
condition
organ,
but
inflammation
may
be
exacerbated
passenger
leucocytes
that
emerge
from
perfusion.
There
evidence
damaged
can
recover
prolonged
advantageous.
In
successful
7-day
has
been
achieved.
delivery
agents
aid
repair
used
modify
reduce
immunogenicity
or
change
structure
blood
group
antigens
create
universal
donor
organ.
Key
Messages:
application
growing
area
research
increasingly
clinic.
future,
offer
opportunity
practice.
If
preserved
for
days
system,
become
elective
rather
than
emergency
procedure.
ability
therapies
effective
way
treat
avoid
complexity
treating
recipient.
Язык: Английский
Avancées et perspectives en préservation d’allotransplantations de tissus composites
Bulletin de l Académie Nationale de Médecine,
Год журнала:
2024,
Номер
208(9), С. 1299 - 1308
Опубликована: Окт. 18, 2024
Язык: Английский
Lung-resident CD3−NK1.1+CD69+CD103+ Cells Play an Important Role in Bacillus Calmette–Guérin Vaccine–Induced Protective Immunity against Mycobacterium tuberculosis Infection
Olamipejo Durojaye,
Abhinav Vankayalapati,
Padmaja Paidipally
и другие.
The Journal of Immunology,
Год журнала:
2024,
Номер
213(5), С. 669 - 677
Опубликована: Июль 15, 2024
Tissue-resident
immune
cells
play
important
roles
in
local
tissue
homeostasis
and
infection
control.
There
is
no
information
on
the
functional
role
of
lung-resident
CD3-NK1.1+CD69+CD103+
intranasal
Bacillus
Calmette-Guérin
(BCG)-vaccinated
and/or
Mycobacterium
tuberculosis
(Mtb)-infected
mice.
Therefore,
we
phenotypically
functionally
characterized
these
mice
vaccinated
intranasally
with
BCG.
We
found
that
BCG
vaccination
increased
CD3-NK1.1+
a
tissue-resident
phenotype
(CD69+CD103+)
lungs
during
first
7
d
after
vaccination.
Three
months
post-BCG
vaccination,
Mtb
induced
expansion
(lung-resident)
lung.
Adoptive
transfer
from
BCG-vaccinated
to
Mtb-infected
naive
resulted
lower
bacterial
burden
reduced
inflammation
lungs.
Our
findings
demonstrated
induces
provide
protection
against
infection.
Язык: Английский