Current Opinion in Psychiatry, Год журнала: 2023, Номер 37(1), С. 1 - 2
Опубликована: Ноя. 30, 2023
aIter Psychology Practices, Wrocław, Poland bDepartment of Psychological Medicine, Institute Psychiatry, & Neuroscience, King's College London, UK Correspondence to Tomasz M. Gondek, MD, PhD, Iter ul. Zakładowa 9G/4, 50-231 Poland. E-mail: [email protected]
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8675 - 8675
Опубликована: Авг. 8, 2024
Omega-3 polyunsaturated fatty acids have received considerable attention in the field of mental health, particular regarding treatment depression. This review presents an overview current research on role omega-3 prevention and depressive disorders. The existing body evidence demonstrates that acids, eicosapentaenoic acid (EPA) docosahexaenoic (DHA), antidepressant effects can be attributed to their modulation neuroinflammation, neurotransmitter function, neuroplasticity. Nevertheless, clinical trials supplementation yielded inconsistent results. Some studies demonstrated significant reductions symptoms following treatment, whereas others shown minimal no beneficial impact. A range factors, encompassing dosage, ratio EPA DHA, baseline nutritional status, been identified as having a potential impact noted Furthermore, it has suggested may act adjunctive for those undergoing treatment. Notwithstanding these encouraging findings, discrepancies study designs variability individual responses underscore necessity further order establish uniform, standardized guidelines use management
Язык: Английский
Процитировано
13
Journal of Medical Economics, Год журнала: 2025, Номер 28(1), С. 235 - 244
Опубликована: Янв. 22, 2025
Inadequate response to antidepressant therapy (ADT) is common in major depressive disorder (MDD); atypical antipsychotic (AA) adjunctive may be effective for these patients. This study aimed compare healthcare resource utilization (HRU) and costs between patients initiating the AA cariprazine as their first vs those subsequently. The Merative MarketScan Commercial Database (January 1, 2015, June 30, 2021) was used identify US adults with MDD ≥1 pharmacy claim ADT 2018 or after. Rates of mental health (MH)‑related all‑cause HRU per patient-year (PPY) mean per-patient-per-year (PPPY) were assessed after initiated therapy. compared cohorts using rate ratios (RRs) cost differences, respectively, estimated from multivariable regression models. Of 838 receiving cariprazine, 44.7% ADT, 55.3% it Those had significantly lower rates MH‑related hospitalizations (RR [95% confidence interval] = 0.55 [0.30, 0.90], p .020) outpatient (OP) visits (0.67 [0.57, 0.82], < .001) PPY than Moreover, annual total (mean difference -$2,182 [-$4,206, -$69], .040), driven primarily by OP visit (-$1,511 [-$2,330, -$615], .001). Similar trends observed all-cause costs. a retrospective analysis secondary data limited follow-up. Claims proxy use. Results this real‑world commercially insured suggest that rather subsequent could help mitigate considerable economic burden appropriate
Язык: Английский
Процитировано
0
Frontiers in Psychiatry, Год журнала: 2025, Номер 16
Опубликована: Март 11, 2025
Objective This study is a cohort of depressive disorder patients with liver qi stagnation syndrome specified under the theory Integrated Chinese and Western Medicine (ICWM). They were measured hemodynamic activity, using fNIRS assessment verbal fluency task (VFT) pre-treatment post-treatment, to examine neurophysiological characteristics, explore impact drug treatment on it. Methods recruited who diagnosed episodes according DSM-V diagnostic Traditional (TCM) criteria in outpatient department Yuquan Hospital Tsinghua University. 35 met recruited. All treated selective serotonin reuptake inhibitors (SSRIs) drugs. The clinical evaluation, VFT performed post-treatment two times. After 3 months treatment, again as follow-up for third time. Results There statistically significant differences HAMD scores between ( p =0.037), total significantly decreased assessment. lDLPFC mPFC activation during was increased after compared pretreatment assessment, CH13( = 0.003) CH30 0.035), improvement at remained CH13 0.007). Conclusion indicates that improved this can remain stable. Hemodynamic reflect changes brain function one-month even before symptoms depression liver-qi syndrome. Physiological indicators like result may better than ethological HAMD.
Язык: Английский
Процитировано
0
Biochemical Genetics, Год журнала: 2025, Номер unknown
Опубликована: Март 16, 2025
Язык: Английский
Процитировано
0
Frontiers in Psychiatry, Год журнала: 2025, Номер 16
Опубликована: Март 18, 2025
disorders can be episodic or recurrent, depending on clinical, personal and social variables (McIntyre et al., 2023;Sampogna 2024).Most patients with major depression report an incomplete inadequate clinical remission, many residual symptoms, cognitive dysfunctions working impairment (Luciano 2023;Demyttenaere, 2019); up to one out of three do not fully respond currently available treatments. According the FDA EMA, are considered have treatment-resistant (TRD) when they fail ≥2 successive adequate trials antidepressants in a single episode (FDA, 2019; 2020). The terminology, definition usefulness concept TRD is debatable for multiple reasons (Demyttenaere & Van Duppen, 2018). First, difficult-to-treat (multiple) treatment failure probably less stigmatizing terms. Second, it has been demonstrated that there no meaningful cut-offs between having experienced 2, 3 4 consecutive failures suggesting more continuous 'staging models' failures.Third, we lack studies scientifically guide clinicians what after 1, (guidelines rather consensus based than evidence based). Despite these conceptual comments, common condition, prevalence rate ranging from 30-to 40% treated antidepressants, associated high levels societal burden. Treatment-resistant significant burden patients, caregivers families, increasing disability worsening quality life. Although several sociodemographic, contextual psychological factors Given number submissions accepted papers extremely good quality, definitely consider present research topic successful.However, despite growing interest (from its diagnosis options), information collected cannot as conclusive yet, but represent basis future studies. We grateful all researchers, participated studies, committed further increase knowledge field.
Язык: Английский
Процитировано
0
Frontiers in Behavioral Neuroscience, Год журнала: 2025, Номер 19
Опубликована: Апрель 7, 2025
Cognitive impairments are frequently observed in subjects with severe mental illnesses (SMI), leading to a remarkable impact their real-world functioning. Well-validated and gold standard instruments available for the assessment of cognitive deficits, but different limitations should be considered, such as need specific training, lengthy administration times, practice effects, or reliance on subjective reports. Recent advances digital technologies, ecological momentary assessments (EMA), virtual reality (VR), passive phenotyping (DP), offer promising complementary approaches capturing In current mini-review, we examine research gaps that limit application these focus feasibility, reliability validity. EMA may capture functioning by increasing number evaluations throughout day, its use might hindered high participant burden missing data. Furthermore, achieve an accurate interpretation EMA, studies account sampling moment selection biases presence several confounding factors. DP faces significant ethical logistical challenges, including privacy informed consent concerns, well challenges data interpretation. VR could serve platform both more ecologically valid rehabilitation interventions, barriers include technological psychometric limitations, underdeveloped theoretical frameworks, considerations. Addressing issues is crucial ensuring novel technologies can effectively valuable complements traditional neuropsychological batteries.
Язык: Английский
Процитировано
0
Trials, Год журнала: 2025, Номер 26(1)
Опубликована: Апрель 17, 2025
The concomitant presence of major depressive disorder (MDD) and opioid use (OUD) poses a formidable clinical challenge, warranting effective interventions that address both psychiatric addictive components. This study sought to compare the efficacy adjunctive ketamine buprenorphine in mitigating anxiety symptom severity craving intensity individuals with co-occurring MDD OUD. A randomized, double-blind trial was conducted, involving meeting diagnostic criteria for Participants were randomly assigned receive or buprenorphine, conjunction standard addiction treatments. Anxiety assessed using Hamilton Rating Scale (HAM-A), Opioid Craving after 2 h, 24 7 days. findings revealed distinct treatment trajectories, demonstrating rapid substantial reduction within hours administration, accompanied by pronounced decline intensity. In contrast, associated more gradual but sustained improvement symptoms over several days, paralleled modest initial craving, followed persistent attenuation. conclusion, this randomized provides evidence supporting Ketamine Buprenorphine reducing patients IRCT20211214053411N1.
Язык: Английский
Процитировано
0
Behavioral Sciences, Год журнала: 2024, Номер 14(3), С. 219 - 219
Опубликована: Март 8, 2024
Background: Depression is highly prevalent and a significant cause of mortality morbidity across the globe. Although antidepressants and/or psychotherapy are often used to treat depression, some recent studies indicate that exercise may play an important role in lowering depression symptoms among patients meeting clinical criteria depressive episode. Objectives: This study aimed evaluate mental health wellbeing adult participants diagnosed with major disorder (MDD) after fourteen weeks receiving supervised physical program. Methods: In pre-post design, assessments were performed at baseline, seven following intervention program using facilitated self-reported psychometric scales. The Beck Inventory (BDI-2) Clinical Outcomes Routine Evaluation—Outcome Measure (CORE-OM) assess depression. short form International Physical Activity Questionnaire (IPAQ) was for self-reporting participants’ activity. Results: At beginning study, baseline total mean scores standard deviations BDI-2, CORE-OM, IPAQ both genders did not differ significantly (p-value > 0.05). Patients showed improvement all assessment scales completing Based on score dropped from 31.25 (indicating moderate severe depression) 14.25 mild minimal depression), p-value <0.001. CORE-OM reduced 1.91 0.98 < 0.005 indicating effective symptoms. MET-minutes/week increased 1713.22 4367.62, weekly P.E. intake; however, change statistically (p = 0.07). Conclusions: Exercise treatment linked considerable therapeutic MDD, particularly when sustained over time. BDI-2 decreased fourteen-week programme, Our findings offer insightful information primary care doctors psychiatrists, prescribing depressed be helpful adjunctive therapy.
Язык: Английский
Процитировано
2
PLoS ONE, Год журнала: 2024, Номер 19(8), С. e0307428 - e0307428
Опубликована: Авг. 22, 2024
Background Previous studies evaluating the association between prediabetes and depression have shown inconsistent results. Consequently, aim of systematic review meta-analysis was to investigate whether is associated with in general population. Methods Relevant observational were obtained by searching Medline, Web Science, Embase databases. A random-effects model utilized pool results incorporating influence heterogeneity. Multiple subgroup analysis performed evaluate study characteristics on outcome. Results Sixteen large-scale cross-sectional involving 322,863 participants included. Among total participants, 82,154 (25.4%) had prediabetes. The pooled showed that a higher prevalence this population (odds ratio [OR]: 1.16, 95% confidence interval [CI]: 1.05 1.28, p = 0.003; I 2 58%). Subgroup stronger younger subjects (<50 years old, OR: 1.25, CI: 1.04 1.50) than older (≥50 1.05, 1.10 1.10; for difference 0.03). Other characteristics, such as country, sex definition prediabetes, methods detection depression, quality score, did not seem significantly affect ( all > 0.05). Conclusions Prediabetes may be slightly population, particularly aged <50 old.
Язык: Английский
Процитировано
1
Heliyon, Год журнала: 2024, Номер 10(19), С. e39026 - e39026
Опубликована: Окт. 1, 2024
This study summarizes the significance of microRNA-134 (miRNA-134) in pathophysiology, diagnosis, and treatment depression, a disease still under investigation due to its complexity. miRNA-134 is an endogenous short non-coding RNA that can bind 3' untranslated region (3'UTR) miRNA-134, inhibiting gene translation showing great potential regulation mood, synaptic plasticity, neuronal function. included 15 articles retrieved from four English-language databases: PubMed, Embase, The Cochrane Library, Web Science, three Chinese literature CNKI, Wanfang, Science Technology Periodical Database (VIP).We evaluated each using Critical Appraisal Skills Program (CASP) tool.The standard integrates analyzes genomic, transcriptomic, neuroimaging, behavioral data analyses related depression. A multidimensional framework based on standardized criteria was used for quality assessment. main findings indicate significantly affects plasticity neurotransmitter regulation, particular synthesis release serotonin dopamine. shows high sensitivity specificity as biomarker diagnosis depression has therapeutic targeted plays crucial role pathogenesis providing valuable insights early development strategies. work highlights focal point advancing personalized medicine approaches
Язык: Английский
Процитировано
1