Targeting the prefrontal-supplementary motor network in obsessive-compulsive disorder with intensified electrical stimulation in two dosages: a randomized, controlled trial DOI Creative Commons
Jaber Alizadehgoradel, Behnam Molaei,

Khandan Barzegar Jalali

и другие.

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 5, 2024

Abstract Obsessive-compulsive disorder (OCD) is associated with a high disease burden, and treatment options are limited. We used intensified electrical stimulation in two dosages to target main circuitry the pathophysiology of OCD, left dorsolateral prefrontal cortex (l-DLPFC), pre-supplementary motor area (pre-SMA) assessed clinical outcomes, neuropsychological performance, brain physiology. In double-blind, randomized controlled trial, thirty-nine patients OCD were randomly assigned three groups sham, 2-mA, or 1-mA transcranial direct current (tDCS) targeting l-DLPFC (F3) pre-SMA (FC2) anodal cathodal respectively. The included 10 sessions 20-minute delivered twice per day 20-min between-session intervals. Outcome measures reduction symptoms, anxiety, depressive states, performance on test battery (response inhibition, working memory, attention), oscillatory activities, functional connectivity. All outcome except EEG examined at pre-intervention, post-intervention, 1-month follow-up times. 2-mA protocol significantly reduced depression states improved quality life after intervention up compared sham group, while symptoms only state immediately following intervention. Both protocols partially response attention bias OCD-related stimuli reaction time memory performance. increased alpha power, decreased delta power as well. connectivity higher frequency bands frontal-central areas sham. Modulation prefrontal-supplementary network tDCS ameliorates results beneficial cognitive effects. resulted larger symptom more converging variables related therapeutic efficacy. These support applying prefrontal-SMA trials.

Язык: Английский

Targeting the prefrontal-supplementary motor network in obsessive-compulsive disorder with intensified electrical stimulation in two dosages: a randomized, controlled trial DOI Creative Commons
Jaber Alizadehgoradel, Behnam Molaei,

Khandan Barzegar Jalali

и другие.

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 5, 2024

Abstract Obsessive-compulsive disorder (OCD) is associated with a high disease burden, and treatment options are limited. We used intensified electrical stimulation in two dosages to target main circuitry the pathophysiology of OCD, left dorsolateral prefrontal cortex (l-DLPFC), pre-supplementary motor area (pre-SMA) assessed clinical outcomes, neuropsychological performance, brain physiology. In double-blind, randomized controlled trial, thirty-nine patients OCD were randomly assigned three groups sham, 2-mA, or 1-mA transcranial direct current (tDCS) targeting l-DLPFC (F3) pre-SMA (FC2) anodal cathodal respectively. The included 10 sessions 20-minute delivered twice per day 20-min between-session intervals. Outcome measures reduction symptoms, anxiety, depressive states, performance on test battery (response inhibition, working memory, attention), oscillatory activities, functional connectivity. All outcome except EEG examined at pre-intervention, post-intervention, 1-month follow-up times. 2-mA protocol significantly reduced depression states improved quality life after intervention up compared sham group, while symptoms only state immediately following intervention. Both protocols partially response attention bias OCD-related stimuli reaction time memory performance. increased alpha power, decreased delta power as well. connectivity higher frequency bands frontal-central areas sham. Modulation prefrontal-supplementary network tDCS ameliorates results beneficial cognitive effects. resulted larger symptom more converging variables related therapeutic efficacy. These support applying prefrontal-SMA trials.

Язык: Английский

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