The BTB-ZF gene Bm-mamo regulates pigmentation in silkworm caterpillars DOI Creative Commons
Songyuan Wu, Xiaoling Tong,

Chenxing Peng

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Сен. 1, 2023

The color pattern of insects is one the most diverse adaptive evolutionary phenotypes. However, molecular regulation this not fully understood. In study, we found that transcription factor Bm-mamo responsible for black dilute (bd) allele mutations in silkworm. belongs to BTB zinc finger family and orthologous mamo Drosophila melanogaster. This gene has a conserved function gamete production silkworms evolved pleiotropic patterns caterpillars. Using RNAi clustered regularly interspaced short palindromic repeats (CRISPR) technology, showed repressor dark melanin larval epidermis. vitro binding assays expression profiling wild-type mutant larvae, also likely regulates related pigment synthesis cuticular protein genes coordinated manner mediate its role formation. mechanism consistent with dual regulating both structure shape cuticle pigments are embedded within it. study provides new insight into as well construction more complex epidermal features some insects.

Язык: Английский

The BTB-ZF gene Bm-mamo regulates pigmentation in silkworm caterpillars DOI Creative Commons
Songyuan Wu, Xiaoling Tong,

Chenxing Peng

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Сен. 1, 2023

The color pattern of insects is one the most diverse adaptive evolutionary phenotypes. However, molecular regulation this not fully understood. In study, we found that transcription factor Bm-mamo responsible for black dilute (bd) allele mutations in silkworm. belongs to BTB zinc finger family and orthologous mamo Drosophila melanogaster. This gene has a conserved function gamete production silkworms evolved pleiotropic patterns caterpillars. Using RNAi clustered regularly interspaced short palindromic repeats (CRISPR) technology, showed repressor dark melanin larval epidermis. vitro binding assays expression profiling wild-type mutant larvae, also likely regulates related pigment synthesis cuticular protein genes coordinated manner mediate its role formation. mechanism consistent with dual regulating both structure shape cuticle pigments are embedded within it. study provides new insight into as well construction more complex epidermal features some insects.

Язык: Английский

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