No detectable fitness cost of infection by cell-fusing agent virus in Aedes aegypti mosquitoes
Royal Society Open Science,
Год журнала:
2024,
Номер
11(1)
Опубликована: Янв. 1, 2024
mosquitoes
are
well-known
vectors
of
arthropod-borne
viruses
(arboviruses).
Mosquitoes
more
frequently
infected
with
insect-specific
(ISVs)
that
cannot
infect
vertebrates.
Some
ISVs
interfere
arbovirus
replication
in
mosquito
vectors,
which
has
gained
attention
for
potential
use
against
transmission.
Cell-fusing
agent
virus
(CFAV),
a
widespread
ISV,
can
reduce
dissemination
Язык: Английский
Prolonged exposure to heat enhances mosquito tolerance to viral infection
Communications Biology,
Год журнала:
2025,
Номер
8(1)
Опубликована: Фев. 4, 2025
How
and
to
what
extent
mosquito-virus
interaction
is
influenced
by
climate
change
a
complex
question
of
ecological
epidemiological
relevance.
We
worked
at
the
intersection
between
thermal
biology
vector
immunology
studied
shifts
in
tolerance
resistance
cell
fusing
agent
virus
(CFAV),
prominent
component
mosquito
virome
known
contribute
shaping
competence,
warm-acclimated
warm-evolved
Aedes
albopictus
mosquitoes.
show
that
length
challenge
influences
outcome
infection
with
mosquitoes
being
more
tolerant
CFAV
infection,
while
resistant
suffering
from
extensive
fitness
costs.
These
results
highlight
importance
considering
fluctuations
immunity
relation
understand
natural
variation
response
viruses
frame
realistic
transmission
models.
Single
versus
multi-generational
exposure
increased
temperature
alters
immune
viral
implications
for
interactions
under
global
change.
Язык: Английский
Spatiotemporal prevalence and characterization of the lineage I insect-specific flavivirus, Quang Binh virus, isolated from Culex gelidus mosquitoes in Singapore
Christopher Chong Wei Ang,
Angelica Ting Yi Ang,
Jerald Yam
и другие.
Journal of General Virology,
Год журнала:
2025,
Номер
106(6)
Опубликована: Июнь 2, 2025
Insect-specific
flaviviruses
(ISFs)
are
a
group
of
orthoflaviviruses
that
can
replicate
efficiently
in
arthropods
but
unable
to
vertebrate
hosts.
This
contrasts
with
medically
important
orthoflaviviruses,
such
as
dengue
virus
(DENV)
and
West
Nile
(WNV).
Using
the
established
monoclonal
antibody
against
viral
RNA
intermediates
cell
assay,
we
report
first
isolation
an
ISF,
Quang
Binh
(QBV),
Singapore
from
three
pools
Culex
gelidus
mosquitoes.
To
determine
spatiotemporal
prevalence
QBV,
total
17,070
mosquitoes,
represented
721
pools,
were
screened
using
QBV-specific
reverse
transcriptase
quantitative
PCR
revealing
36
QBV-positive
mosquitoes
detected
mainly
along
northern
coastal
regions
Singapore.
Repeated
detections
over
12
months
north-western
nature
reserve
suggest
local
stable
establishment
virus.
Phylogenetic
molecular
analyses
show
QBV
sequences
together
other
Southeast
Asian
Cx.
-derived
phylogenetically
distinct
those
derived
tritaeniorhynchus
.
We
also
present
vitro
evidence
is
able
suppress
DENV2
WNV
KUN
C6/36
cells
by
2.9
logs
1.8
logs,
respectively.
represents
known
study
ISF
highlights
QBV’s
potential
biological
control
orthoflaviviruses.
Язык: Английский
Prolonged thermal stress enhances mosquito tolerance to viral infection
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 9, 2024
Summary
How
and
to
what
extent
mosquito-virus
interaction
is
influenced
by
climate
change
a
complex
question
of
ecological
epidemiological
relevance.
We
worked
at
the
intersection
between
thermal
biology
vector
immunology
studied
shifts
in
tolerance
resistance
cell
fusing
agent
virus
(CFAV),
prominent
component
mosquito
virome
know
contribute
shaping
competence,
warm-acclimated
warm-evolved
Aedes
albopictus
mosquitoes.
show
that
length
challenge
influences
outcome
infection
with
mosquitoes
being
more
tolerant
CFAV
infection,
while
resistant
suffering
from
extensive
fitness
costs.
These
results
highlight
importance
considering
fluctuations
immunity
relation
understand
natural
variation
response
viruses
frame
realistic
transmission
models.
Язык: Английский
Dengue-mediated changes in the vectorial capacity of Aedes aegypti (Diptera: Culicidae): manipulation of transmission or infection by-product?
Journal of Medical Entomology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 22, 2024
Abstract
An
arthropod’s
vectorial
capacity
summarizes
its
disease
transmission
potential.
Life-history
traits,
such
as
fecundity
or
survival,
and
behavioral
locomotor
activity,
host-seeking
feeding
behavior,
are
important
components
of
capacity.
Studies
have
shown
that
mosquito-borne
pathogens
may
alter
traits
their
mosquito
vectors,
thus
directly
impacting
epidemic
Here,
we
compile
discuss
the
evidence
supporting
dengue-mediated
changes
in
yellow
fever
Aedes
aegypti
(L.),
primary
vector,
evaluate
whether
observed
effects
represent
an
evolved
trait
manipulation
with
epidemiological
implications.
Dengue
infection
appears
to
manipulate
essential
facilitate
vector–host
contact,
host-seeking,
but
underlying
mechanisms
still
not
understood.
Conversely,
life-history
relevant
vector
population
dynamics,
oviposition,
fecundity,
appear
be
negatively
impacted
by
dengue
virus.
Overall,
any
detrimental
on
a
negligible
cost
derived
from
virulence
has
manipulating
Ae.
behavior
performance.
However,
methodological
disparities
among
studies
render
comparisons
difficult
limit
ability
reach
well-supported
conclusions.
This
highlights
need
for
more
standardized
methods
research
into
virus-mediated
traits.
Eventually,
argue
outlined
here
must
considered
when
assessing
impact
other
arbovirus–vector–host
interactions.
Язык: Английский