Dengue-mediated changes in the vectorial capacity of Aedes aegypti (Diptera: Culicidae): manipulation of transmission or infection by-product? DOI Creative Commons

Ioana Mateescu,

Sébastian Lequime

Journal of Medical Entomology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

Abstract An arthropod’s vectorial capacity summarizes its disease transmission potential. Life-history traits, such as fecundity or survival, and behavioral locomotor activity, host-seeking feeding behavior, are important components of capacity. Studies have shown that mosquito-borne pathogens may alter traits their mosquito vectors, thus directly impacting epidemic Here, we compile discuss the evidence supporting dengue-mediated changes in yellow fever Aedes aegypti (L.), primary vector, evaluate whether observed effects represent an evolved trait manipulation with epidemiological implications. Dengue infection appears to manipulate essential facilitate vector–host contact, host-seeking, but underlying mechanisms still not understood. Conversely, life-history relevant vector population dynamics, oviposition, fecundity, appear be negatively impacted by dengue virus. Overall, any detrimental on a negligible cost derived from virulence has manipulating Ae. behavior performance. However, methodological disparities among studies render comparisons difficult limit ability reach well-supported conclusions. This highlights need for more standardized methods research into virus-mediated traits. Eventually, argue outlined here must considered when assessing impact other arbovirus–vector–host interactions.

Язык: Английский

No detectable fitness cost of infection by cell-fusing agent virus in Aedes aegypti mosquitoes DOI Creative Commons
Yasutsugu Suzuki, Takahiro Suzuki, Fuminari Miura

и другие.

Royal Society Open Science, Год журнала: 2024, Номер 11(1)

Опубликована: Янв. 1, 2024

mosquitoes are well-known vectors of arthropod-borne viruses (arboviruses). Mosquitoes more frequently infected with insect-specific (ISVs) that cannot infect vertebrates. Some ISVs interfere arbovirus replication in mosquito vectors, which has gained attention for potential use against transmission. Cell-fusing agent virus (CFAV), a widespread ISV, can reduce dissemination

Язык: Английский

Процитировано

5
Prolonged exposure to heat enhances mosquito tolerance to viral infection DOI Creative Commons
Hugo D. Perdomo, Ayda Khorramnejad,

Nfamara M. Cham

и другие.

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Фев. 4, 2025

How and to what extent mosquito-virus interaction is influenced by climate change a complex question of ecological epidemiological relevance. We worked at the intersection between thermal biology vector immunology studied shifts in tolerance resistance cell fusing agent virus (CFAV), prominent component mosquito virome known contribute shaping competence, warm-acclimated warm-evolved Aedes albopictus mosquitoes. show that length challenge influences outcome infection with mosquitoes being more tolerant CFAV infection, while resistant suffering from extensive fitness costs. These results highlight importance considering fluctuations immunity relation understand natural variation response viruses frame realistic transmission models. Single versus multi-generational exposure increased temperature alters immune viral implications for interactions under global change.

Язык: Английский

Процитировано

0
Spatiotemporal prevalence and characterization of the lineage I insect-specific flavivirus, Quang Binh virus, isolated from Culex gelidus mosquitoes in Singapore DOI

Christopher Chong Wei Ang,

Angelica Ting Yi Ang,

Jerald Yam

и другие.

Journal of General Virology, Год журнала: 2025, Номер 106(6)

Опубликована: Июнь 2, 2025

Insect-specific flaviviruses (ISFs) are a group of orthoflaviviruses that can replicate efficiently in arthropods but unable to vertebrate hosts. This contrasts with medically important orthoflaviviruses, such as dengue virus (DENV) and West Nile (WNV). Using the established monoclonal antibody against viral RNA intermediates cell assay, we report first isolation an ISF, Quang Binh (QBV), Singapore from three pools Culex gelidus mosquitoes. To determine spatiotemporal prevalence QBV, total 17,070 mosquitoes, represented 721 pools, were screened using QBV-specific reverse transcriptase quantitative PCR revealing 36 QBV-positive mosquitoes detected mainly along northern coastal regions Singapore. Repeated detections over 12 months north-western nature reserve suggest local stable establishment virus. Phylogenetic molecular analyses show QBV sequences together other Southeast Asian Cx. -derived phylogenetically distinct those derived tritaeniorhynchus . We also present vitro evidence is able suppress DENV2 WNV KUN C6/36 cells by 2.9 logs 1.8 logs, respectively. represents known study ISF highlights QBV’s potential biological control orthoflaviviruses.

Язык: Английский

Процитировано

0
Prolonged thermal stress enhances mosquito tolerance to viral infection DOI Creative Commons
Hugo D. Perdomo, Ayda Khorramnejad,

Nfamara M. Cham

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Summary How and to what extent mosquito-virus interaction is influenced by climate change a complex question of ecological epidemiological relevance. We worked at the intersection between thermal biology vector immunology studied shifts in tolerance resistance cell fusing agent virus (CFAV), prominent component mosquito virome know contribute shaping competence, warm-acclimated warm-evolved Aedes albopictus mosquitoes. show that length challenge influences outcome infection with mosquitoes being more tolerant CFAV infection, while resistant suffering from extensive fitness costs. These results highlight importance considering fluctuations immunity relation understand natural variation response viruses frame realistic transmission models.

Язык: Английский

Процитировано

0
Dengue-mediated changes in the vectorial capacity of Aedes aegypti (Diptera: Culicidae): manipulation of transmission or infection by-product? DOI Creative Commons

Ioana Mateescu,

Sébastian Lequime

Journal of Medical Entomology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

Abstract An arthropod’s vectorial capacity summarizes its disease transmission potential. Life-history traits, such as fecundity or survival, and behavioral locomotor activity, host-seeking feeding behavior, are important components of capacity. Studies have shown that mosquito-borne pathogens may alter traits their mosquito vectors, thus directly impacting epidemic Here, we compile discuss the evidence supporting dengue-mediated changes in yellow fever Aedes aegypti (L.), primary vector, evaluate whether observed effects represent an evolved trait manipulation with epidemiological implications. Dengue infection appears to manipulate essential facilitate vector–host contact, host-seeking, but underlying mechanisms still not understood. Conversely, life-history relevant vector population dynamics, oviposition, fecundity, appear be negatively impacted by dengue virus. Overall, any detrimental on a negligible cost derived from virulence has manipulating Ae. behavior performance. However, methodological disparities among studies render comparisons difficult limit ability reach well-supported conclusions. This highlights need for more standardized methods research into virus-mediated traits. Eventually, argue outlined here must considered when assessing impact other arbovirus–vector–host interactions.

Язык: Английский

Процитировано

0