Modelling Hollow Microneedle-Mediated Drug Delivery in Skin Considering Drug Binding
Pharmaceutics,
Год журнала:
2025,
Номер
17(1), С. 105 - 105
Опубликована: Янв. 14, 2025
Background/Objectives:
Microneedle(MN)-based
drug
delivery
is
one
of
the
potential
approaches
to
overcome
limitations
oral
and
hypodermic
needle
delivery.
An
in
silico
model
has
been
developed
for
hollow
microneedle
(HMN)-based
skin
its
subsequent
absorption
blood
tissue
compartments
presence
interstitial
flow.
The
drug’s
reversible
specific
saturable
binding
receptors
kinetics
across
have
taken
into
account.
Methods:
governing
equations
representing
flow
fluid,
transport
verapamil
viable
concentrations
are
solved
using
combined
Marker
Cell
Immersed
Boundary
Methods
gain
a
quantitative
understanding
under
consideration.
Results:
viscoelastic
predicted
impede
and,
hence,
reduce
all
forms
compartments.
findings
reveal
that
higher
mean
concentration
not
always
associated
with
longer
MN
length.
Simulations
also
predict
bound
compartment
rise
decreasing
tip
diameters.
In
contrast,
free
increases
increasing
injection
velocities.
Conclusions:
novelty
this
study
includes
metabolism
two-dimensional
irregular
nonlinear,
specific,
saturable,
compartment.
diameter
velocity
thought
serve
as
regulatory
parameters
effectiveness
efficacy
MN-mediated
therapy
if
robust
enough
sustain
force
needed
penetrate
wider
skin.
Язык: Английский
Modelling receptor-mediated endocytosis in hollow microneedle-based verapamil delivery through viscoelastic skin
Computer Methods in Biomechanics & Biomedical Engineering,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Март 20, 2025
Drug
delivered
from
the
microneedle
(MN)
tip
diffuses
across
viscoelastic
skin
before
entering
blood
compartment
and
being
absorbed.
Reversible
uptake
kinetics
between
tissue
compartments,
reversible
specific
saturable
binding
with
its
receptors,
endocytosis
are
given
due
attention.
Simulations
predict
that,
unlike
thinning,
viscoelasticity
a
higher
Young's
modulus
value,
as
in
an
older
person,
inhibit
verapamil
diffusion
within
skin,
metabolism
stabilises
concentrations
compartments.
Simultaneously,
irreversible
improve
drug
compartment,
facilitating
receptor-mediated
endocytosis.
The
results
also
that
internalised
increases
time
at
slower
internalisation
rates;
however,
rates,
it
attains
peak
value
gradually
diminishing.
Furthermore,
rate
of
lysosomal
degradation
escalates,
concentration
diminishes
shifts
upward.
A
comprehensive
sensitivity
analysis
has
been
performed
because
uncertainty
about
several
crucial
parameters.
Our
findings
align
well
existing
literature.
Язык: Английский