A diabetes-like biochemical and behavioural phenotype of Drosophila induced by predator stress DOI Creative Commons
Tatjana Krama,

Diana Bahhir,

Liina Ots

и другие.

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2023, Номер 290(2002)

Опубликована: Июль 5, 2023

Predation can have both lethal and non-lethal effects on prey. The of predation instil changes in prey life history, behaviour, morphology physiology, causing adaptive evolution. chronic stress caused by sustained is comparable to conditions humans. Conditions like anxiety, depression, post-traumatic syndrome also been implicated the development metabolic disorders such as obesity diabetes. In this study, we found that predator induced during larval fruit flies Drosophila melanogaster impairs carbohydrate metabolism systemic inhibition Akt protein kinase, which a central regulator glucose uptake. However, grown with predators survived better under direct spider adult phase. Administration metformin 5-hydroxytryptophan (5-HTP), precursor neurotransmitter serotonin, reversed these effects. Our results demonstrate link between impairment, suggesting diabetes-like biochemical phenotype may be terms survival reproductive success. We provide novel animal model explore mechanisms responsible for onset disorders, are highly prevalent human populations.

Язык: Английский

A diabetes-like biochemical and behavioural phenotype of Drosophila induced by predator stress DOI Creative Commons
Tatjana Krama,

Diana Bahhir,

Liina Ots

и другие.

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2023, Номер 290(2002)

Опубликована: Июль 5, 2023

Predation can have both lethal and non-lethal effects on prey. The of predation instil changes in prey life history, behaviour, morphology physiology, causing adaptive evolution. chronic stress caused by sustained is comparable to conditions humans. Conditions like anxiety, depression, post-traumatic syndrome also been implicated the development metabolic disorders such as obesity diabetes. In this study, we found that predator induced during larval fruit flies Drosophila melanogaster impairs carbohydrate metabolism systemic inhibition Akt protein kinase, which a central regulator glucose uptake. However, grown with predators survived better under direct spider adult phase. Administration metformin 5-hydroxytryptophan (5-HTP), precursor neurotransmitter serotonin, reversed these effects. Our results demonstrate link between impairment, suggesting diabetes-like biochemical phenotype may be terms survival reproductive success. We provide novel animal model explore mechanisms responsible for onset disorders, are highly prevalent human populations.

Язык: Английский

Процитировано

1