Diversification and recurrent adaptation of the synaptonemal complex in Drosophila
PLoS Genetics,
Год журнала:
2025,
Номер
21(1), С. e1011549 - e1011549
Опубликована: Янв. 13, 2025
The
synaptonemal
complex
(SC)
is
a
protein-rich
structure
essential
for
meiotic
recombination
and
faithful
chromosome
segregation.
Acting
like
zipper
to
paired
homologous
chromosomes
during
early
prophase
I,
the
symmetrical
where
central
elements
are
connected
on
two
sides
by
transverse
filaments
chromatin-anchoring
lateral
elements.
Despite
being
found
in
most
major
eukaryotic
taxa
implying
deeply
conserved
evolutionary
origin,
several
components
of
exhibit
unusually
high
rates
sequence
turnover.
This
puzzlingly
exemplified
SC
Drosophila
,
display
no
identifiable
homologs
outside
genus.
Here,
we
exhaustively
examine
history
taking
comparative
phylogenomic
approach
with
species
density
circumvent
obscured
homology
due
rapid
evolution.
Contrasting
starkly
against
other
genes
involved
pairing,
show
significantly
elevated
coding
evolution
combination
relaxed
constraint
recurrent,
widespread
positive
selection.
In
particular,
element
cona
filament
c(3)
G
have
diversified
through
tandem
retro-duplications,
repeatedly
generating
paralogs
novel
germline
activity.
striking
case
molecular
convergence,
that
independently
arose
distant
lineages
evolved
under
selection
convergent
truncations
protein
termini
testes
expression.
Surprisingly,
expression
prone
change
suggesting
recurrent
regulatory
which,
many
species,
resulted
even
though
males
achiasmic.
Overall,
our
study
recapitulates
poor
conservation
components,
further
uncovers
lack
extends
modalities
including
copy
number,
genomic
locale,
regulation.
Considering
common
ancestor,
suggest
activity
male
germline,
while
still
poorly
understood,
may
be
prime
target
constant
pressures
driving
repeated
adaptations
innovations.
Язык: Английский
The adaptive value of recombination in resolving intralocus sexual conflict by gene duplication
Proceedings of the Royal Society B Biological Sciences,
Год журнала:
2025,
Номер
292(2039)
Опубликована: Янв. 1, 2025
Recombination
plays
a
key
role
in
increasing
the
efficacy
of
selection.
We
investigate
whether
recombination
can
also
play
resolving
adaptive
conflicts
at
loci
coding
for
traits
shared
between
sexes.
Errors
during
events
resulting
gene
duplications
may
provide
long-term
evolutionary
advantage
if
those
experience
sexually
antagonistic
(SA)
selection
since,
after
duplication,
sex-specific
expression
profiles
will
be
free
to
evolve,
thereby
reducing
load
on
population
fitness
and
conflict.
The
potential
duplication
tempered
by
short-term
deleterious
effects
gamete
zygote
survival,
which
tolerable
species
with
high
reproductive
output
but
not
low
output.
used
datasets
candidate
SA
from
Drosophila
melanogaster
humans
test
these
ideas.
As
humans,
alleles
flies
net
positive
across
two
sexes
occurred
higher
frequencies
than
negative
effects.
In
flies,
rates
were
associated
more
intense
levels
sexual
conflict
genes
paralogues
occur
regions
rates,
indicating
are
history
Genes
experiencing
showed
both
proportion
numbers
paralogues.
Together,
our
findings
reveal
multiple
lines
evidence
possible
route
towards
resolution
an
via
that
is
facilitated
rates.
Язык: Английский
The resolution of evolutionary conflicts within species
Proceedings of the Royal Society B Biological Sciences,
Год журнала:
2024,
Номер
291(2031)
Опубликована: Сен. 1, 2024
Evolutionary
conflicts
of
interest
occur
at
all
levels,
scales
and
forms
biological
organization.
They
are
a
fundamental
component
the
living
world
range
from
between
genetic
elements
cells,
to
sexes
competing
individuals.
Yet,
existence
admirably
well
functioning
genomes,
bodies,
mating
pairs
societies
suggests
that
processes
must
exist
resolve
or
mitigate
such
conflicts.
We
organized
this
special
feature
‘The
resolution
evolutionary
within
species’
encourage
flow
knowledge
fields
traditionally
have
often
taken
different
approaches
study
Contributed
papers
discuss
data
bacteria,
plants
animals
(including
humans)
present
theory,
molecular
mechanisms
population
dynamics
how
resolved
in
nature.
Together,
they
contribute
synthetic
theory
conflict
resolution.
Язык: Английский
Predation affects the evolution of sex-specific longevity
Biology Letters,
Год журнала:
2024,
Номер
20(11)
Опубликована: Ноя. 1, 2024
Predation,
a
major
cause
of
natural
selection,
is
classically
thought
to
target
the
weak
and
sick.
However,
predators
can
animals
with
condition-dependent
sexual
traits,
therefore,
high-quality
individuals
also
be
focus
predation.
Thus,
it
not
always
clear
which
are
foci
or
how
this
affects
trait
evolution.
Here,
we
tested
for
evolutionary
effects
sex-specific
predation
on
male
female
longevity
using
replicate
populations
broad-horned
flour
beetle
Gnatocerus
cornutus
.
We
found
that
male-limited
resulted
in
evolution
reduced
increased
longevity,
while
female-limited
had
no
either
sex.
document
costs
reproduction.
Coupled
other
findings,
our
results
suggest
impacts
males
and,
because
negative
intersexual
genetic
correlations,
increases
longevity.
Язык: Английский