De novo evolution of transmissible tumours in hydra DOI Creative Commons
Sophie Tissot,

Jordan Meliani,

Justine Boutry

и другие.

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2024, Номер 291(2031)

Опубликована: Сен. 1, 2024

While most cancers are not transmissible, there rare cases where cancer cells can spread between individuals and even across species, leading to epidemics. Despite their significance, the origins of such remain elusive due late detection in host populations. Using Hydra oligactis , which exhibits spontaneous tumour development that some strains became vertically transmitted, this study presents first experimental observation evolution a transmissible tumour. Specifically, we assessed initial vertical transmission rate tumours explored potential for optimizing through artificial selection. One hydra strains, evolved over five generations, was characterized by analysis cell type bacteriome, assessment life-history traits. Our findings indicate be immediate enhanced The resulting overproliferation large interstitial stem associated with specific bacteriome. Furthermore, despite only generations transmission, these induced notable alterations traits, hinting at compensatory response. This work, therefore, makes contribution understanding conditions emergence short-term consequences host.

Язык: Английский

Ecology of vertical tumor transmission in the freshwater cnidarian Hydra oligactis DOI Creative Commons

Nikita Stepanskyy,

Michel Pascal,

Klara Asselin

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

0
De novo evolution of transmissible tumours in hydra DOI Creative Commons
Sophie Tissot,

Jordan Meliani,

Justine Boutry

и другие.

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2024, Номер 291(2031)

Опубликована: Сен. 1, 2024

While most cancers are not transmissible, there rare cases where cancer cells can spread between individuals and even across species, leading to epidemics. Despite their significance, the origins of such remain elusive due late detection in host populations. Using Hydra oligactis , which exhibits spontaneous tumour development that some strains became vertically transmitted, this study presents first experimental observation evolution a transmissible tumour. Specifically, we assessed initial vertical transmission rate tumours explored potential for optimizing through artificial selection. One hydra strains, evolved over five generations, was characterized by analysis cell type bacteriome, assessment life-history traits. Our findings indicate be immediate enhanced The resulting overproliferation large interstitial stem associated with specific bacteriome. Furthermore, despite only generations transmission, these induced notable alterations traits, hinting at compensatory response. This work, therefore, makes contribution understanding conditions emergence short-term consequences host.

Язык: Английский

Процитировано

2