Time to start taking time seriously: how to investigate unexpected biological rhythms within infectious disease research DOI Creative Commons
Rachel S. Edgar, Aidan J. O’Donnell, Xiaodong Zhuang

и другие.

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2025, Номер 380(1918)

Опубликована: Янв. 23, 2025

The discovery of rhythmicity in host and pathogen activities dates back to the Hippocratic era, but causes consequences these biological rhythms have remained poorly understood. Rhythms infection phenotypes or traits are observed across taxonomically diverse hosts pathogens, suggesting general evolutionary principles. Understanding principles may enable be leveraged manners that improve drug vaccine efficacy disrupt timekeeping reduce virulence transmission. Explaining exploiting infections require an integrative multidisciplinary approach, which is a hallmark research within chronobiology. Many researchers welcomed into chronobiology from other fields after observing unexpected rhythm time-of-day effect their data. Such findings can launch rich new topic, engaging with concepts, approaches dogma discipline daunting. Fortunately, has well-developed frameworks for interrogating readily applied novel contexts. Here, we provide ‘how to’ guide exploring daily infectious disease research. We outline how establish: whether circadian, what extent responsible, relevance host–pathogen interactions, explore therapeutic potential. This article part Theo Murphy meeting issue ‘Circadian immunity’.

Язык: Английский

Time to start taking time seriously: how to investigate unexpected biological rhythms within infectious disease research DOI Creative Commons
Rachel S. Edgar, Aidan J. O’Donnell, Xiaodong Zhuang

и другие.

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2025, Номер 380(1918)

Опубликована: Янв. 23, 2025

The discovery of rhythmicity in host and pathogen activities dates back to the Hippocratic era, but causes consequences these biological rhythms have remained poorly understood. Rhythms infection phenotypes or traits are observed across taxonomically diverse hosts pathogens, suggesting general evolutionary principles. Understanding principles may enable be leveraged manners that improve drug vaccine efficacy disrupt timekeeping reduce virulence transmission. Explaining exploiting infections require an integrative multidisciplinary approach, which is a hallmark research within chronobiology. Many researchers welcomed into chronobiology from other fields after observing unexpected rhythm time-of-day effect their data. Such findings can launch rich new topic, engaging with concepts, approaches dogma discipline daunting. Fortunately, has well-developed frameworks for interrogating readily applied novel contexts. Here, we provide ‘how to’ guide exploring daily infectious disease research. We outline how establish: whether circadian, what extent responsible, relevance host–pathogen interactions, explore therapeutic potential. This article part Theo Murphy meeting issue ‘Circadian immunity’.

Язык: Английский

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