Impacts of ribosomal RNA sequence variation on gene expression and phenotype DOI Creative Commons
Griffin A. Welfer, Ryan A. Brady,

S. Kundhavai Natchiar

и другие.

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2025, Номер 380(1921)

Опубликована: Март 6, 2025

Since the framing of Central Dogma, it has been speculated that physically distinct ribosomes within cells may influence gene expression and cellular physiology. While heterogeneity in ribosome composition reported bacteria, protozoans, fungi, zebrafish, mice humans, its functional implications remain actively debated. Here, we review recent evidence demonstrating conserved variant ribosomal DNA (rDNA) alleles humans renders their translating pool intrinsically heterogeneous at level RNA (rRNA). In this context, discuss reports nutrient limitation-induced stress Escherichia coli leads to changes rRNA allele expression, programmatically altering transcription phenotype. We highlight expressing from operons exhibit drug sensitivities, which can be recapitulated vitro potentially rationalized by subtle perturbations structure or dynamic properties. Finally, differential rDNA results different populations subtypes mammalian tissues. These findings motivate further research into impacts heterogeneities on function predict strategies targeting hold therapeutic potential.This article is part discussion meeting issue 'Ribosome diversity impact protein synthesis, development disease'.

Язык: Английский

Impacts of ribosomal RNA sequence variation on gene expression and phenotype DOI Creative Commons
Griffin A. Welfer, Ryan A. Brady,

S. Kundhavai Natchiar

и другие.

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2025, Номер 380(1921)

Опубликована: Март 6, 2025

Since the framing of Central Dogma, it has been speculated that physically distinct ribosomes within cells may influence gene expression and cellular physiology. While heterogeneity in ribosome composition reported bacteria, protozoans, fungi, zebrafish, mice humans, its functional implications remain actively debated. Here, we review recent evidence demonstrating conserved variant ribosomal DNA (rDNA) alleles humans renders their translating pool intrinsically heterogeneous at level RNA (rRNA). In this context, discuss reports nutrient limitation-induced stress Escherichia coli leads to changes rRNA allele expression, programmatically altering transcription phenotype. We highlight expressing from operons exhibit drug sensitivities, which can be recapitulated vitro potentially rationalized by subtle perturbations structure or dynamic properties. Finally, differential rDNA results different populations subtypes mammalian tissues. These findings motivate further research into impacts heterogeneities on function predict strategies targeting hold therapeutic potential.This article is part discussion meeting issue 'Ribosome diversity impact protein synthesis, development disease'.

Язык: Английский

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