Host mitochondria: more than an organelle in SARS-CoV-2 infection
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Авг. 25, 2023
Since
December
2019,
the
world
has
been
facing
viral
pandemic
called
COVID-19
(Coronavirus
disease
2019)
caused
by
a
new
beta-coronavirus
named
severe
acute
respiratory
syndrome
coronavirus-2,
or
SARS-CoV-2.
patients
may
present
with
wide
range
of
symptoms,
from
asymptomatic
to
requiring
intensive
care
support.
The
form
is
often
marked
an
altered
immune
response
and
cytokine
storm.
Advanced
age,
age-related
underlying
diseases,
including
metabolic
syndromes,
appear
contribute
increased
severity
mortality
suggesting
role
for
mitochondria
in
pathogenesis.
Furthermore,
since
system
associated
its
damage-related
molecular
patterns
(mtDAMPs),
host
mitochondrial
play
important
during
infections.
Viruses
have
evolved
modulate
function
survival
proliferation,
which
turn
could
lead
cellular
stress
progression.
Recent
studies
focused
on
possible
roles
SARS-CoV-2
infection.
It
suggested
that
hijacking
be
key
factor
In
this
review,
we
discuss
infections
infection
based
past
knowledge.
Paying
attention
will
help
better
understand
pathophysiology
achieve
effective
methods
prevention,
diagnosis,
treatment.
Язык: Английский
The interplay of EBV virus and cell metabolism in lung cancer
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(22)
Опубликована: Ноя. 1, 2024
Abstract
Epstein–Barr
virus
infection
has
been
implicated
in
various
cancers,
including
lung
cancer,
where
it
influences
cellular
metabolism
to
promote
tumorigenesis.
This
review
examines
the
complex
interplay
between
and
cell
highlighting
viral
mechanisms
of
metabolic
reprogramming
their
implications
for
therapeutic
strategies.
Key
proteins
such
as
LMP1
LMP2A
manipulate
glycolysis,
glutaminolysis
lipid
support
replication
immune
evasion
within
tumour
microenvironment.
Understanding
these
interactions
provides
insights
into
novel
approaches
targeting
viral‐induced
vulnerabilities
virus‐associated
cancer.
Язык: Английский