Actinobacteria in natural products research: Progress and prospects

Microbiological Research, Год журнала: 2021, Номер 246, С. 126708 - 126708

Опубликована: Янв. 22, 2021

Язык: Английский

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Extreme environments: microbiology leading to specialized metabolites

Journal of Applied Microbiology, Год журнала: 2019, Номер 128(3), С. 630 - 657

Опубликована: Июль 16, 2019

The prevalence of multidrug-resistant microbial pathogens due to the continued misuse and overuse antibiotics in agriculture medicine is raising prospect a return preantibiotic days at time diminishing numbers drug leads. good news that an increased understanding nature extent diversity natural habitats coupled with application new technologies microbiology chemistry opening up strategies search for specialized products therapeutic properties. This review explores premise harsh environmental conditions extreme biomes, notably deserts, permafrost soils deep-sea sediments select micro-organisms, especially actinobacteria, cyanobacteria fungi, potential synthesize druggable molecules. There evidence over past decade micro-organisms adapted life are rich source metabolites. Extreme by their very tend be fragile hence there need conserve those known hot-spots novel gifted needed drive discovery campaigns innovative biotechnology. also provides overview microbial-derived molecules biological activities focusing on period from 2010 until 2018, this 186 structures were isolated 129 representatives taxa recovered habitats.

Язык: Английский

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Actinobacteria From Desert: Diversity and Biotechnological Applications

Frontiers in Microbiology, Год журнала: 2021, Номер 12

Опубликована: Дек. 9, 2021

Deserts, as an unexplored extreme ecosystem, are known to harbor diverse actinobacteria with biotechnological potential. Both multidrug-resistant (MDR) pathogens and environmental issues have sharply raised the emerging demand for functional actinobacteria. From 2000 2021, 129 new species been continuously reported from 35 deserts worldwide. The two largest numbers of members genera Streptomyces Geodermatophilus , followed by other extremophilic strains such alkaliphiles, halotolerant species, thermophiles, psychrotolerant species. Improved isolation strategies recovery culturable unculturable desert crucial exploration their diversity offer a better understanding survival mechanisms under stresses. main bioprospecting processes involve target on selective media incubation selection representatives plates further investigations. Bioactive compounds obtained being explored potential, especially in medicine. To date, there more than 50 novel discovered these gifted potential antimicrobial activities, including anti-MDR anti-inflammatory, antivirus, antifungal, antiallergic, antibacterial, antitumor, cytotoxic activities. A range plant growth-promoting abilities inspired great interest agricultural In addition, several degradative, oxidative, enzymes can be applied industry environment. This review aims provide comprehensive overview environments remarkable source while rich offers underexplored resource exploitations.

Язык: Английский

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Shedding light on the composition of extreme microbial dark matter: alternative approaches for culturing extremophiles

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Июнь 2, 2023

More than 20,000 species of prokaryotes (less 1% the estimated number Earth's microbial species) have been described thus far. However, vast majority microbes that inhabit extreme environments remain uncultured and this group is termed "microbial dark matter." Little known regarding ecological functions biotechnological potential these underexplored extremophiles, representing a untapped uncharacterized biological resource. Advances in cultivation approaches are key for detailed comprehensive characterization roles shaping environment and, ultimately, their exploitation, such as extremophile-derived bioproducts (extremozymes, secondary metabolites, CRISPR Cas systems, pigments, among others), astrobiology, space exploration. Additional efforts to enhance culturable diversity required due challenges imposed by culturing plating conditions. In review, we summarize methods technologies used recover environments, while discussing advantages disadvantages associated with each approaches. Additionally, review describes alternative strategies retrieve novel taxa unknown genes, metabolisms, roles, ultimate goal increasing yields more efficient bio-based products. This summarizes unveil hidden microbiome discusses directions future studies matter its applications biotechnology astrobiology.

Язык: Английский

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The co-inoculation of Pseudomonas chlororaphis H1 and Bacillus altitudinis Y1 promoted soybean [Glycine max (L.) Merrill] growth and increased the relative abundance of beneficial microorganisms in rhizosphere and root

Frontiers in Microbiology, Год журнала: 2023, Номер 13

Опубликована: Янв. 9, 2023

Currently, plant growth-promoting rhizobacteria (PGPR) microbial inoculants are heavily used in agricultural production among which Pseudomonas sp. and Bacillus two excellent inoculum strains, widely growth promotion disease control. However, few studies have been conducted on the combined use of bacteria. The aim this study was to investigate effects co-inoculation these bacteria soybean [Glycine max (L.) Merrill] physiological indexes further effect native soil bacterial communities endophyte microbiota, especially microorganisms rhizosphere root. A pot experiment four treatments were designed: group without any strain inoculant (CK); inoculated with chlororaphis H1 (J); altitudinis Y1 (Y) equal volume P. B. (H). Compared CK, three groups J, Y, H exhibited improved indexes, most significant (p < 0.05). In terms community structure, relative abundance Luteimonas (9.31%) higher than J (6.07%), Y (3.40%), CK (5.69%) groups, has potential value suppression. Besides, compared other roots, increased beneficial for contents Allorhizobium-Neorhizobium-Pararhizobium-Rhizobium, Devosia, Methylobacillus significantly conclusion, we found that composite could effectively promote growth, increase yield improve root certain improvement.

Язык: Английский

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Effects of coastal saline-alkali soil on rhizosphere microbial community and crop yield of cotton at different growth stages

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Апрель 19, 2024

Soil salinization is a global constraint that significantly hampers agricultural production, with cotton being an important cash crop not immune to its detrimental effects. The rhizosphere microbiome plays critical role in plant health and growth, which assists plants resisting adverse abiotic stresses including soil salinization. This study explores the impact of on cotton, effects yield, physical chemical properties, as well bacterial community structures. results β-diversity analysis showed there were significant differences communities saline-alkali at different growth stages cotton. Besides, more severity salinization, abundance Proteobacteria , Bacteroidota enriched composition where Acidobacteriota exhibited opposite trend. And co-occurrence network affected complexity network. These findings provide valuable insights into mechanisms by affects microorganisms offer guidance for improving using beneficial microorganisms.

Язык: Английский

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Difficult-to-culture bacteria in the rhizosphere: The underexplored signature microbial groups

Pedosphere, Год журнала: 2021, Номер 32(1), С. 75 - 89

Опубликована: Дек. 8, 2021

Язык: Английский

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Marine microbial bioprospecting: Exploitation of marine biodiversity towards biotechnological applications—a review

Journal of Basic Microbiology, Год журнала: 2022, Номер 62(9), С. 1030 - 1043

Опубликована: Апрель 25, 2022

Abstract The increase in the human population causes an demand for nutritional supplies and energy resources. Thus, novel, natural, renewable resources became of great interest. Here comes optimistic role bioprospecting as a promising tool to isolate novel interesting molecules microorganisms from marine environment alternatives existing Bioprospecting metabolites with high biotechnological potentials has gained wide interest due variability richness environment. Indeed, existence extreme conditions that increases adaptability organisms, especially planktons, allow presence biological species are able produce compounds multiple health benefits economical value. This review aims provide comprehensive overview microbial growing field It emphasizes functional facilitates discovery metabolites. Marine was also discussed legal aspect first time, focusing on shortcomings international law. We summarized challenges facing including economic feasibility issues.

Язык: Английский

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Saccharopolyspora karakumensis sp. nov., Saccharopolyspora elongata sp. nov., Saccharopolyspora aridisoli sp. nov., Saccharopolyspora terrae sp. nov. and their biotechnological potential revealed by genome analysis

Systematic and Applied Microbiology, Год журнала: 2021, Номер 44(6), С. 126270 - 126270

Опубликована: Окт. 5, 2021

Язык: Английский

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Generation of a high quality library of bioactive filamentous actinomycetes from extreme biomes using a culture-based bioprospecting strategy

Frontiers in Microbiology, Год журнала: 2023, Номер 13

Опубликована: Янв. 19, 2023

Filamentous actinomycetes, notably members of the genus

Язык: Английский

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