Uncovering the Organization of Neural Circuits with Generalized Phase Locking Analysis DOI Open Access
Shervin Safavi, Theofanis I. Panagiotaropoulos, Vishal Kapoor

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2020, Номер unknown

Опубликована: Дек. 10, 2020

Abstract Despite the considerable progress of in vivo neural recording techniques, inferring biophysical mechanisms underlying large scale coordination brain activity from data remains challenging. One obstacle is difficulty to link high dimensional functional connectivity measures mechanistic models network activity. We address this issue by investigating spike-field coupling (SFC) measurements, which quantify synchronization between, on one hand, action potentials produced neurons, and other hand a mesoscopic “field” signals, reflecting subthreshold activities at possibly multiple sites. As number sites gets large, amount pairwise SFC measurements becomes overwhelmingly challenging interpret. develop Generalized Phase Locking Analysis (GPLA) as dimensionality reduction multivariate SFC. GPLA describes dominant between field ensembles across space frequencies, thereby providing rich yet interpretable information. In particular, we show that features are biophysically when used conjunction with appropriate models, such can identify influence circuit properties these features. demonstrate statistical benefits interpretability approach various computational Utah array recordings. The results suggest jointly modeling help uncover contribution recurrent microcircuits spatio-temporal dynamics observed multi-channel experimental

Язык: Английский

An active role of inferior frontal cortex in conscious experience DOI Creative Commons
Veith Weilnhammer, Merve Fritsch, Meera Chikermane

и другие.

Current Biology, Год журнала: 2021, Номер 31(13), С. 2868 - 2880.e8

Опубликована: Май 13, 2021

In the search for neural correlates of consciousness, it has remained controversial whether prefrontal cortex determines what is consciously experienced or, alternatively, serves only complementary functions, such as introspection or action. Here, we provide converging evidence from computational modeling and two functional magnetic resonance imaging experiments that indicated a key role inferior frontal in detecting perceptual conflicts caused by ambiguous sensory information. Crucially, detection turned out to be critical process transforming information into unambiguous conscious experiences: third experiment, disruption activity through transcranial stimulation slowed down updating experience occurs response conflicts. These findings show actively contributes resolution ambiguities. Prefrontal thus causally involved determining contents experience.

Язык: Английский

Процитировано

61
Prefrontal Cortex and Consciousness: Beware of the Signals DOI Creative Commons
Theofanis I. Panagiotaropoulos, Abhilash Dwarakanath, Vishal Kapoor

и другие.

Trends in Cognitive Sciences, Год журнала: 2020, Номер 24(5), С. 343 - 344

Опубликована: Март 10, 2020

Язык: Английский

Процитировано

38
Binocular rivalry reveals an out-of-equilibrium neural dynamics suited for decision-making DOI Creative Commons

Robin Cao,

Alexander Pastukhov, Stepan Aleshin

и другие.

eLife, Год журнала: 2021, Номер 10

Опубликована: Авг. 9, 2021

In ambiguous or conflicting sensory situations, perception is often 'multistable' in that it perpetually changes at irregular intervals, shifting abruptly between distinct alternatives. The interval statistics of these alternations exhibits quasi-universal characteristics, suggesting a general mechanism. Using binocular rivalry, we show many aspects this perceptual dynamics are reproduced by hierarchical model operating out equilibrium. constitutive elements idealize the metastability cortical networks. Independent accumulate visual evidence one level, while groups coupled compete for dominance another level. As soon as group dominates perception, feedback inhibition suppresses supporting evidence. Previously unreported features serial dependencies compellingly corroborate Moreover, proposed out-of-equilibrium satisfies normative constraints continuous decision-making. Thus, multistable may reflect decision-making volatile world: integrating over space and time, choosing categorically hypotheses, concurrently evaluating

Язык: Английский

Процитировано

28
Evidence for an Active Role of Inferior Frontal Cortex in Conscious Experience DOI Open Access
Veith Weilnhammer, Merve Fritsch, Meera Chikermane

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2020, Номер unknown

Опубликована: Май 30, 2020

2 Abstract In the search for neural correlates of consciousness, it has remained controversial whether prefrontal cortex determines what is consciously experienced or, alternatively, serves only complementary functions such as introspection or action. Here, we provide converging evidence from computational modeling and two functional magnetic resonance imaging experiments a key role inferior frontal in detecting perceptual conflicts that emerge ambiguous sensory information. Crucially, detection by turned out to be critical process transforming information into unambiguous conscious experiences: third experiment, disruption activity through transcranial stimulation slowed down updating experience occurs response conflicts. These findings show actively contributes resolution ambiguities. Prefrontal thus causally involved determining contents experience. 3 One-sentence Summary Inferior detects resolves conflict during bistable perception.

Язык: Английский

Процитировано

7
Spontaneously emerging internal models of visual sequences combine abstract and event-specific information in the prefrontal cortex DOI Creative Commons
Marie E. Bellet,

Marion Gay,

Joachim Bellet

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2021, Номер unknown

Опубликована: Окт. 5, 2021

SUMMARY When exposed to sensory sequences, do macaque monkeys spontaneously form abstract internal models that generalize novel experiences? Here, we show neuronal populations in ventrolateral prefrontal cortex encode visual sequences by factorizing them into separate codes for the specific pictures presented and their sequential structure. Ventrolateral neurons were recorded while passively viewed sequence mismatches local-global paradigm. Even without any overt task or response requirements, built up representations of structure, serial order, image identity within distinct but superimposed subspaces. Representations structure rapidly updated following single exposure a mismatch sequence, orthogonal represent different complexity. Finally, those generalized across same comprising images. These results suggest rich reflect both content-specific information.

Язык: Английский

Процитировано

5
Evidence for an Active Role of Inferior Frontal Cortex in Conscious Experience DOI
Veith Weilnhammer

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2020, Номер unknown

Опубликована: Авг. 5, 2020

Despite a growing understanding of human brain function, it is still unclear how conscious experience emerges from neural activity. A much-debated question in the search for underpinnings consciousness whether prefrontal cortex actively shapes or, alternatively, serves only complementary cognitive functions such as evaluating and acting on contents consciousness. Here, we studied mechanisms bistable perception to elucidate role Human participants reported periodic changes that were induced by conflicting sensory information. Two functional magnetic resonance imaging experiments showed activity inferior frontal signals conflict between available In third experiment, inhibitory transcranial stimulation revealed disruption leads decrease conflict-driven experience. Our results indicate that, engaging iterative reciprocal interactions with regions, plays critical both detection resolution perceptual conflicts. This points causal influence dynamic unfolding

Язык: Английский

Процитировано

4
A decision-theoretic model of multistability: perceptual switches as internal actions DOI Creative Commons
Shervin Safavi, Peter Dayan

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

Abstract Perceptual multistability has been studied for centuries using a diverse collection of approaches. Insights derived from this phenomenon range core principles information processing, such as perceptual inference, to high-level concerns, visual awareness. The dominant computational explanations are based on the Helmholtzian view perception inverse inference. However, these approaches struggle account crucial role played by value, e.g., with percepts paired reward dominating longer periods than unpaired ones. In study, we formulate in terms dynamic, value-based, choice, employing formalism partially observable Markov decision process (POMDP). We use binocular rivalry an example, considering different explicit and implicit sources (and punishment) each percept. resulting values time-dependent influenced novelty form exploration. solution POMDP is optimal policy, show that can replicate explain several characteristics rivalry, ranging classic hallmarks apparently spontaneous random switches approximately gamma-distributed dominance more subtle aspects rich temporal dynamics switching rates. Overall, our decision-theoretic perspective not only accounts wealth unexplained data, but also opens up modern conceptions internal reinforcement learning service understanding phenomena, sensory processing generally.

Язык: Английский

Процитировано

0
Space, Time, Categories, Mechanics, and Consciousness: On Kant and Neuroscience DOI

K. Hepp

Journal of Statistical Physics, Год журнала: 2020, Номер 180(1-6), С. 896 - 909

Опубликована: Апрель 25, 2020

Язык: Английский

Процитировано

2
Uncovering the Organization of Neural Circuits with Generalized Phase Locking Analysis DOI Open Access
Shervin Safavi, Theofanis I. Panagiotaropoulos, Vishal Kapoor

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2020, Номер unknown

Опубликована: Дек. 10, 2020

Abstract Despite the considerable progress of in vivo neural recording techniques, inferring biophysical mechanisms underlying large scale coordination brain activity from data remains challenging. One obstacle is difficulty to link high dimensional functional connectivity measures mechanistic models network activity. We address this issue by investigating spike-field coupling (SFC) measurements, which quantify synchronization between, on one hand, action potentials produced neurons, and other hand a mesoscopic “field” signals, reflecting subthreshold activities at possibly multiple sites. As number sites gets large, amount pairwise SFC measurements becomes overwhelmingly challenging interpret. develop Generalized Phase Locking Analysis (GPLA) as dimensionality reduction multivariate SFC. GPLA describes dominant between field ensembles across space frequencies, thereby providing rich yet interpretable information. In particular, we show that features are biophysically when used conjunction with appropriate models, such can identify influence circuit properties these features. demonstrate statistical benefits interpretability approach various computational Utah array recordings. The results suggest jointly modeling help uncover contribution recurrent microcircuits spatio-temporal dynamics observed multi-channel experimental

Язык: Английский

Процитировано

1