The collaborative study on the genetics of alcoholism: Genetics DOI Creative Commons
Emma C. Johnson, Jessica E. Salvatore, Dongbing Lai

и другие.

Genes Brain & Behavior, Год журнала: 2023, Номер 22(5)

Опубликована: Июнь 30, 2023

Abstract This review describes the genetic approaches and results from family‐based Collaborative Study on Genetics of Alcoholism (COGA). COGA was designed during linkage era to identify genes affecting risk for alcohol use disorder (AUD) related problems, among first AUD‐focused studies subsequently adopt a genome‐wide association (GWAS) approach. COGA's structure, multimodal assessment with gold‐standard clinical neurophysiological data, availability prospective longitudinal phenotyping continues provide insights into etiology AUD disorders. These include investigations trajectories substance disorders, phenome‐wide loci interest, pleiotropy, social genomics, nurture, within‐family comparisons. is one few genetics projects that includes substantial number participants African ancestry. The sharing data biospecimens has been cornerstone project, key contributor large‐scale GWAS consortia. wealth publicly available extensive unique adaptable resource our understanding traits.

Язык: Английский

The collaborative study on the genetics of alcoholism: Genetics DOI Creative Commons
Emma C. Johnson, Jessica E. Salvatore, Dongbing Lai

и другие.

Genes Brain & Behavior, Год журнала: 2023, Номер 22(5)

Опубликована: Июнь 30, 2023

Abstract This review describes the genetic approaches and results from family‐based Collaborative Study on Genetics of Alcoholism (COGA). COGA was designed during linkage era to identify genes affecting risk for alcohol use disorder (AUD) related problems, among first AUD‐focused studies subsequently adopt a genome‐wide association (GWAS) approach. COGA's structure, multimodal assessment with gold‐standard clinical neurophysiological data, availability prospective longitudinal phenotyping continues provide insights into etiology AUD disorders. These include investigations trajectories substance disorders, phenome‐wide loci interest, pleiotropy, social genomics, nurture, within‐family comparisons. is one few genetics projects that includes substantial number participants African ancestry. The sharing data biospecimens has been cornerstone project, key contributor large‐scale GWAS consortia. wealth publicly available extensive unique adaptable resource our understanding traits.

Язык: Английский

Процитировано

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