Vaccine- and Breakthrough Infection-Elicited Pre-Omicron Immunity More Effectively Neutralizes Omicron BA.1, BA.2, BA.4 and BA.5 Than Pre-Omicron Infection Alone

Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(2), С. 1741 - 1761

Опубликована: Фев. 19, 2023

Since the emergence of SARS-CoV-2 Omicron BA.1 and BA.2, several sublineages have emerged, supplanting their predecessors. Here we compared neutralization BA.1, BA.4 BA.5 by human sera collected from individuals who were infected with ancestral B.1 (D614G) strain, vaccinated (3 doses) or breakthrough infection pre-Omicron strains (Gamma Delta). All exhibited extensive escape all when to strain Delta, albeit different levels depending on origin sera. Convalescent unable neutralize partly neutralized BA.5. Vaccinee but evaded neutralizing antibodies (NAb). Some infections (BTI) non-neutralizing. Neutralizing BTI had similar ability against sublineages. Despite anti-Spike anti-Receptor Binding Domain (RBD) in groups, highest cross-neutralizing convalescent least neutralizing. Antibody avidity inferred NT50:antibody titer ratio was patients, underscoring qualitative differences elicited vaccination. Together, these findings highlight importance vaccination trigger highly cross-reactive that phylogenetically antigenically distant strains, suggest immune imprinting first generation vaccines may restrict, not abolish, cross-neutralization.

Язык: Английский

Specific convulsions and brain damage in children hospitalized for Omicron BA.5 infection: an observational study using two cohorts

World Journal of Pediatrics, Год журнала: 2024, Номер 20(10), С. 1079 - 1089

Опубликована: Май 7, 2024

SARS-CoV-2 continues to mutate over time, and reports on children infected with Omicron BA.5 are limited. We aimed analyze the specific symptoms of Omicron-infected improve patient care.

Язык: Английский

Time-course characterization of whole-transcriptome dynamics of HepG2/C3A spheroids and its toxicological implications

Toxicology Letters, Год журнала: 2024, Номер 401, С. 125 - 138

Опубликована: Окт. 3, 2024

Язык: Английский