
Neuron, Год журнала: 2023, Номер 112(1), С. 93 - 112.e10
Опубликована: Дек. 13, 2023
Язык: Английский
Neuron, Год журнала: 2023, Номер 112(1), С. 93 - 112.e10
Опубликована: Дек. 13, 2023
Язык: Английский
eNeuro, Год журнала: 2023, Номер 10(6), С. ENEURO.0090 - 23.2023
Опубликована: Июнь 1, 2023
Vestibulospinal neurons integrate sensed imbalance to regulate postural reflexes. As an evolutionarily conserved neural population, understanding their synaptic and circuit-level properties can offer insight into vertebrate antigravity Motivated by recent work, we set out verify extend the characterization of vestibulospinal in larval zebrafish. Using current-clamp recordings together with stimulation, observed that zebrafish are silent at rest, yet capable sustained spiking following depolarization. Neurons responded systematically a vestibular stimulus (translation dark); responses were abolished after chronic or acute loss utricular otolith. Voltage-clamp rest revealed strong excitatory inputs characteristic multimodal distribution amplitudes, as well inhibitory inputs. Excitatory within particular mode (amplitude range) routinely violated refractory period criteria exhibited complex sensory tuning, suggesting nonunitary origin. Next, using unilateral loss-of-function approach, characterized source from each ear. We systematic high-amplitude lesions ipsilateral, but not contralateral, recorded neuron. In contrast, while some had decreased either ipsilateral contralateral lesions, there no changes across population neurons. conclude otolith shapes through both Our findings expand our how model, zebrafish, might use input stabilize posture. More broadly, when compared other vertebrates, data speak origins input.
Язык: Английский
Процитировано
12Neuron, Год журнала: 2023, Номер 112(1), С. 93 - 112.e10
Опубликована: Дек. 13, 2023
Язык: Английский
Процитировано
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