Abstract
In
this
study,
we
use
integrated
transcriptomic
datasets
from
the
GEO
repository
with
purpose
of
investigating
immune
dysregulation
in
COVID-19.
Thus,
context,
decided
to
be
focused
on
NK
cells
and
CD14+
monocytes
gene
expression,
considering
GSE165461
GSE198256,
respectively.
Other
PBMCs,
lung,
olfactory,
sensory
epithelium
lymph
were
used
provide
robust
validation
for
our
results.
This
approach
gave
an
view
responses
COVID-19,
pointing
out
a
set
potential
biomarkers
therapeutic
targets
special
regard
standards
physiological
conditions.
IFI27,
MKI67,
CENPF,
MBP,
HBA2,
TMEM158,
THBD,
HBA1,
LHFPL2,
SLA,
AC104564.3
identified
as
key
genes
analysis
that
have
critical
biological
processes
related
inflammation,
regulation,
oxidative
stress,
metabolic
processes.
Consequently,
such
are
important
understanding
heterogeneous
clinical
manifestations
COVID-19—from
acute
long-term
effects
now
known
‘long
COVID’.
Subsequent
additional
consolidated
these
role
diagnosis
COVID-19
prediction
its
severity.
Moreover,
their
enrichment
pathophysiological
pathways
presented
them
intervention.The
results
insight
into
molecular
dynamics
caused
by
other
monocytes.
study
constitutes
solid
basis
targeted
diagnostic
development
makes
relevant
contributions
ongoing
research
efforts
toward
better
management
mitigation
pandemic.
Neurotrauma Reports,
Год журнала:
2024,
Номер
5(1), С. 81 - 94
Опубликована: Янв. 1, 2024
Major
determinants
of
the
biological
background
or
reserve,
such
as
age,
sex,
comorbidities
(diabetes,
hypertension,
obesity,
etc.),
and
medications
(e.g.,
anticoagulants),
are
known
to
affect
outcome
after
traumatic
brain
injury
(TBI).
With
unparalleled
data
richness
coronavirus
disease
2019
(COVID-19;
∼375,000
counting!)
well
chronic
form,
long-COVID,
also
called
post-acute
sequelae
SARS-CoV-2
infection
(PASC),
publications
(∼30,000
counting)
covering
virtually
every
aspect
diseases,
pathomechanisms,
biomarkers,
phases,
symptomatology,
etc.,
have
provided
a
unique
opportunity
better
understand
appreciate
holistic
nature
interconnectivity
between
organ
systems,
importance
in
modifying
trajectories
affecting
outcomes.
Such
approach
is
badly
needed
TBI-induced
conditions
their
totality.
Here,
I
briefly
review
what
about
long-COVID/PASC,
its
underlying—suspected—pathologies,
pathobiological
changes
induced
by
TBI,
other
words,
TBI
endophenotypes,
discuss
intersection
long-COVID/PASC
pathobiologies,
how
considering
some
factors
person's
inclusion
mechanistic
molecular
biomarkers
can
help
improve
clinical
management
patients.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 12, 2024
ABSTRACT
Globally,
over
65
million
individuals
are
estimated
to
suffer
from
post-acute
sequelae
of
COVID-19
(PASC).
A
large
number
living
with
PASC
experience
cardiovascular
symptoms
(i.e.
chest
pain
and
heart
palpitations)
(PASC-CVS).
The
role
chronic
inflammation
in
these
symptoms,
particular
persisting
for
>1
year
after
SARS-CoV-2
infection,
remains
be
clearly
defined.
In
this
cross-sectional
study,
blood
samples
were
obtained
three
different
sites
Australia
i)
a
resolved
infection
(and
no
persistent
i.e.
‘Recovered’),
ii)
prolonged
PASC-CVS
iii)
negative
individuals.
Individuals
PASC-CVS,
relative
Recovered
individuals,
had
transcriptomic
signature
associated
inflammation.
This
was
accompanied
by
elevated
levels
pro-inflammatory
cytokines
(IL-12,
IL-1β,
MCP-1
IL-6)
at
approximately
18
months
post-infection.
These
present
trace
amounts,
such
that
they
could
only
detected
the
use
novel
nanotechnology.
Importantly,
trace-level
direct
effect
on
functionality
pluripotent
stem
cell
derived
cardiomyocytes
vitro
.
not
observed
presence
dexamethasone.
Plasma
proteomics
demonstrated
further
differences
between
patients
post-infection
including
enrichment
complement
coagulation
proteins
those
symptoms.
Together,
data
provide
new
insight
into
nanotechnology
as
possible
diagnostic
approach
condition.
Long
COVID,
also
referred
to
as
post-COVID-19
condition,
describes
the
lingering
after-effects
of
COVID-19
infection.
This
complex
syndrome
encompasses
a
range
symptoms
affecting
physical
well-being,
cognitive
function,
and
mental
health.
The
widespread
impact
long
COVID
extends
beyond
individual
sufferers,
placing
significant
strain
on
healthcare
systems
causing
far-reaching
socioeconomic
consequences.
scale
this
multifaceted
health
crisis
is
unparalleled
in
recent
history,
millions
globally
challenging
our
understanding
post-viral
conditions.
study
aimed
explore
possibility
targeting
G
protein-coupled
receptors
(GPCRs)
signaling
pathway-related
genes
therapeutics
for
using
computational
analysis.
Targeting
GPCRs
their
pathways
holds
promise
therapeutics,
these
are
involved
crucial
physiological
processes
including
immune
regulation,
inflammation
control,
neurotransmission.
All
implicated
diverse
persistent
potentially
offering
versatile
approach
addressing
multiple
aspects
condition
simultaneously.
identified
21
associated
with
further
exploration
potential
targets.
Notably,
GPCR
such
HRAS,
KRAS,
GNAQ,
GNA11
were
determined
be
possible
therapeutic
targets
pathophysiological
mechanisms
COVID.
FDA-approved
drugs
identified,
Binimetinib,
Cabozantinib,
Selumetinib,
Panitumumab,
Cetuximab,
Adagrasib,
Tipifarnib,
Sotorasib.
Additionally,
Naltrexone
Tipifarnib
have
emerged
new
treatment
options
SARS-CoV-2
may
hijack
dysregulate
lung
ion
fluid
transport,
contributing
pathophysiology
pulmonary
edema
patients
COVID-19.
Further
research
required
translate
findings
into
development
investigate
relationship
between
viral
infection
signalling.
Abstract
In
this
study,
we
use
integrated
transcriptomic
datasets
from
the
GEO
repository
with
purpose
of
investigating
immune
dysregulation
in
COVID-19.
Thus,
context,
decided
to
be
focused
on
NK
cells
and
CD14+
monocytes
gene
expression,
considering
GSE165461
GSE198256,
respectively.
Other
PBMCs,
lung,
olfactory,
sensory
epithelium
lymph
were
used
provide
robust
validation
for
our
results.
This
approach
gave
an
view
responses
COVID-19,
pointing
out
a
set
potential
biomarkers
therapeutic
targets
special
regard
standards
physiological
conditions.
IFI27,
MKI67,
CENPF,
MBP,
HBA2,
TMEM158,
THBD,
HBA1,
LHFPL2,
SLA,
AC104564.3
identified
as
key
genes
analysis
that
have
critical
biological
processes
related
inflammation,
regulation,
oxidative
stress,
metabolic
processes.
Consequently,
such
are
important
understanding
heterogeneous
clinical
manifestations
COVID-19—from
acute
long-term
effects
now
known
‘long
COVID’.
Subsequent
additional
consolidated
these
role
diagnosis
COVID-19
prediction
its
severity.
Moreover,
their
enrichment
pathophysiological
pathways
presented
them
intervention.The
results
insight
into
molecular
dynamics
caused
by
other
monocytes.
study
constitutes
solid
basis
targeted
diagnostic
development
makes
relevant
contributions
ongoing
research
efforts
toward
better
management
mitigation
pandemic.
