Frontiers in Neurology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

In nature, animals must learn to recognize danger signals and respond immediately threats improve their environmental adaptation. However, excessive fear responses can lead diseases such as post-traumatic stress disorder, wherein traumatic events result in persistent memories. Therefore, erasing pathological memories vivo is a crucial topic neuroscience for understanding the nature of treating clinically relevant diseases. This article reviews recent studies on memory erasure, erasure short- long-term memory, neuroplasticity, neural circuitry molecular mechanisms roles engram cells perineuronal nets erasure. Research mechanism limited, plausible explanation essential difference between extinction still needs be provided. Notably, this review may guide future its underlying mechanisms, which help develop novel treatment strategies anxiety, other mental disorders.

Язык: Английский