bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 27, 2024

Abstract Pregnancy and motherhood (parity) can have long-term effects on cognition brain aging in both humans rodents. Estrogens are related to cognitive function neuroplasticity. improve postmenopausal women, but the evidence is mixed, part due differences hormone therapy dose composition. In addition, past pregnancy influences cognition, with earlier age of first being associated poorer outcomes aging. However, few studies examined specific features history such as or possible mechanisms underlying these changes. We whether maternal at estradiol treatment differentially affected hippocampal neuroplasticity, inflammation, activation, middle-age. Thirteen-month-old rats (who were nulliparous (never mothered) previously primiparous (had a litter) 3 months 7 months) received daily injections (or sesame oil vehicle) for sixteen days tested Morris Water Maze. An older was impaired spatial memory improved performance reversal training, increased new neurons ventral hippocampus compared other groups. Estradiol decreased total activation percent dorsal hippocampus, regardless parity history. also production anti-inflammatory cytokines based pregnancy. This work suggests that affects neuroplasticity neuroinflammation middle age, long lasting structure function.

Язык: Английский