bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 23, 2023

Abstract Recent studies have found dramatic cell-type specific responses to stimulus novelty, highlighting the importance of analyzing cortical circuitry at level granularity understand brain function. Although initial work classified and characterized activity for each cell type, alterations in circuitry—particularly when multiple novelty effects interact—remain unclear. To address this gap, we employed a large-scale public dataset electrophysiological recordings visual cortex awake, behaving mice using Neuropixels probes designed population network models investigate observed changes neural dynamics response combination distinct forms novelty. The model parameters were rigorously constrained by publicly available structural datasets, including multi-patch synaptic physiology electron microscopy data. Our systematic optimization approach identified tens thousands parameter sets that replicate activity. Analysis these solutions revealed generally weaker connections under novel stimuli, as well shift balance e between SST VIP populations. Along with this, PV populations experienced overall more excitatory influences compared results also highlight role neurons aspects processing altering gain saturation conditions. In sum, our findings provide characterization how circuit adapts combining rich datasets.

Язык: Английский