Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk DOI Creative Commons
Thibaux Van der Stede, Alexia Van de Loock, Guillermo Turiel

и другие.

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Plasticity of skeletal muscle is induced by transcriptional and translational events in response to exercise, leading multiple health performance benefits. The microenvironment harbors myofibers mononuclear cells, but the rich cell diversity has been largely ignored relation exercise adaptations. Using our workflow transcriptome profiling individual myofibers, we observed that their exercise-induced was surprisingly modest compared with bulk tissue response. Through integration single-cell data, identified a small mast population likely responsible for histamine secretion during targeting myeloid vascular cells rather than myofibers. We demonstrated through H1 or H2 receptor blockade humans this paracrine signaling cascade drives glycogen resynthesis coordinates Altogether, cellular deconstruction human uncovers histamine-driven intercellular communication network steering recovery adaptation exercise.

Язык: Английский

Interactions of mitochondrial and skeletal muscle biology in mitochondrial myopathy DOI Creative Commons
Valeria Di Leo, Tiago Gomes, Amy E. Vincent

и другие.

Biochemical Journal, Год журнала: 2023, Номер 480(21), С. 1767 - 1789

Опубликована: Ноя. 15, 2023

Mitochondrial dysfunction in skeletal muscle fibres occurs with both healthy aging and a range of neuromuscular diseases. The impact mitochondrial the way adapt to this is important understand disease mechanisms develop therapeutic interventions. Furthermore, interactions between biology, myopathy, likely have implications for normal function physiology. In review, we will try give an overview what known date about these including metabolic remodelling, morphology, turnover, cellular processes cell structure function. Each topics at different stage understanding, some being well researched understood, others their infancy. know comes from models. Whilst findings are confirmed humans, where not yet case, must be cautious interpreting context human disease. Here, our goal discuss known, highlight unknown perspective on future direction research area.

Язык: Английский

Процитировано

9
Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk DOI Creative Commons
Thibaux Van der Stede, Alexia Van de Loock, Guillermo Turiel

и другие.

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Plasticity of skeletal muscle is induced by transcriptional and translational events in response to exercise, leading multiple health performance benefits. The microenvironment harbors myofibers mononuclear cells, but the rich cell diversity has been largely ignored relation exercise adaptations. Using our workflow transcriptome profiling individual myofibers, we observed that their exercise-induced was surprisingly modest compared with bulk tissue response. Through integration single-cell data, identified a small mast population likely responsible for histamine secretion during targeting myeloid vascular cells rather than myofibers. We demonstrated through H1 or H2 receptor blockade humans this paracrine signaling cascade drives glycogen resynthesis coordinates Altogether, cellular deconstruction human uncovers histamine-driven intercellular communication network steering recovery adaptation exercise.

Язык: Английский

Процитировано

0