Assessment of pulmonary fibrosis using weighted gene co-expression network analysis

Frontiers in Toxicology, Год журнала: 2024, Номер 6

Опубликована: Окт. 24, 2024

For many industrial chemicals toxicological data is sparse regarding several regulatory endpoints, so there a high and often unmet demand for NAMs that allow screening prioritization of these chemicals. In this proof concept case study we propose multi-gene biomarkers compounds' ability to induce lung fibrosis demonstrate their application

Язык: Английский

Network Pharmacology and Machine Learning Reveal Salidroside’s Mechanisms in Idiopathic Pulmonary Fibrosis Treatment

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 9453 - 9467

Опубликована: Ноя. 1, 2024

Idiopathic pulmonary fibrosis (IPF) is an irreversible respiratory disease. In this study, we evaluated the efficacy of salidroside (SAL), main component Rhodiola rosea, in treating IPF.

Язык: Английский