Journal of Fungi, Год журнала: 2024, Номер 10(9), С. 638 - 638
Опубликована: Сен. 6, 2024
Vulvovaginal candidiasis (VVC) affects up to 75% of women at least once during their lifetime, and 8% suffer from frequent recurrent episodes VVC (RVVC). A lack a protective host response underlies vaginal
Язык: Английский
Kidney International Reports, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Brain Behavior & Immunity - Health, Год журнала: 2025, Номер 44, С. 100947 - 100947
Опубликована: Янв. 15, 2025
Язык: Английский
Процитировано
0
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Март 18, 2024
Abstract Long COVID, or Post-Acute COVID Syndrome (PACS), may develop following SARS-CoV-2 infection, posing a substantial burden to society. Recently, PACS has been linked persistent activation of the complement system (CS), offering hope for both diagnostic tool and targeted therapy. However, our findings indicate that, after adjusting proteomics data age, body mass index sex imbalances, evidence disappears. Furthermore, proteomic analysis two orthogonal cohorts—one addressing severe acute phase another mild phase—fails support notion CS activation. Instead, we identify signature indicative either ongoing infections sustained immune similar that observed in COVID-19, particularly within mild-PACS cohort.
Язык: Английский
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июнь 23, 2024
Abstract Aging is a fundamental risk factor for wide array of diseases. The Berlin Study II (BASE-II) cohort study designed to investigate the physical, mental, and social determinants successful aging. We utilized high-throughput mass spectrometry measure proteomes 1890 BASE-II participants, divided into two age groups: 27-37 years 60-85 years. employed multiple linear regression analyses explore effects demographic factors such as age, sex, BMI, along with hormonal treatments lifestyle factors, on serum proteome. identify new associations confirm previously described proteins linked BMI contraceptive use (HCU). Notably, we observed that abundance nutrient transport proteins, particularly apolipoproteins, metabolic diseases in aged individuals, including syndrome type 2 diabetes. Additionally, identified specific alterations explained by smoking alcohol consumption. further report significant proteome signature female participants corresponding menopause hormone replacement therapy (MHT). successfully classified these based MHT status an AUROC 0.82 using Complement Component 9 Plasminogen, slightly outperforming estradiol (AUROC: 0.80), active ingredient most preparations. Overall, our underscores impact therapies during aging, primarily affecting components immune system metabolism.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 15, 2024
ABSTRACT Background The use of oral contraceptives among women with pre-existing cardiometabolic risk factors has been associated increased cardiovascular events but the underlying mechanisms are not well understood. Analyzing proteome enables identification and quantification proteins involved in various cellular processes, including those affected by contraceptives. Objective objective this study was to investigate if current contraceptive alterations plasma pre-menopausal African American hypertension Genomics, Environmental Factors, Social Determinants Cardiovascular Disease Americans Study (GENE-FORECAST). Design We evaluated 2,941 serum measured on Olink platform assess associations between contraception protein levels 51 untreated Stage 2 (13 users 38 non-users). A generalized linear model fitted for each protein, adjusting age, body mass index, alcohol consumption, level education, physical activity. Pathway enrichment analysis carried out identify common pathways use. Gene Ontology conducted gain insight into functional characteristics biology. Results identified 44 significantly Among those, 31 showed decreased users, while 13 exhibited an increase users. Fourteen were enriched potentially relevant pathogenesis disease complement coagulation cascades, cholesterol metabolism Notch signaling. There 25 terms encompassing 39 linked use; several these peptidase inhibitor Conclusions This provides novel insights proteomic landscape uncontrolled hypertension.
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Ноя. 4, 2024
Identifying biomarkers able to discriminate individuals on different health trajectories is crucial understand the molecular basis of age-related morbidity. We investigated multi-omics signatures general and organ-specific morbidity, as well their interconnectivity. examined cross-sectional metabolome proteome data from 3,142 adults Cooperative Health Research in South Tyrol (CHRIS) study, an Alpine population study designed investigate how human biology, environment, lifestyle factors contribute people's over time. had 174 metabolites 148 proteins quantified fasting serum plasma samples. used Cumulative Illness Rating Scale (CIRS) Comorbidity Index (CMI), which considers morbidity 14 organ systems, assess status (any vs. healthy). Omics-signatures for were identified using random forest (RF) classifiers. Linear regression models fitted directionality omics markers associations, identify related Next age, we 21 10 relevant predictors results confirmed associations serotonin glutamate be age-independent. Considering several jointly endocrine, cardiovascular, renal To conclude, circulating was a potential novel predictor overall
Язык: Английский
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Март 24, 2024
Abstract Genome-wide association studies identified a locus on chromosome 4q21.1, spanning the FAM47E , STBD1 CCDC158 and SHROOM3 genes, as associated with kidney function markers. Functional implicated encoding an actin-binding protein involved in cell shaping, into podocyte barrier damage. Despite was also found electrolytes, hematological cardiovascular traits, systematic explorations of functional variants across all genes are lacking. We reconstructed haplotypes covering whole 12,834 participants to Cooperative Health Research South Tyrol (CHRIS) study, using genotypes imputed whole-exome sequencing reference panel subsample 3,422 participants. Haplotypes included 146 exonic intronic over four were tested for 73 serum, urine anthropometric 172 serum metabolite 148 plasma concentrations linear regression models. 11 2% 24% frequency. Compared most common haplotype, higher levels creatinine-based estimated glomerular filtration rate lower magnesium levels. The second haplotype (12% frequency) additionally dodecanoyl-, hydroxyvaleryl- tiglyl-carnitine concentrations. A 4% frequency red blood count, hemoglobin, hematocrit glutamine putrescine Cluster analysis revealed distinct groups traits haplotypes. - exhibits variability that corresponds marked pleiotropic effects, implicating existence population subgroups biomarker profiles.
Язык: Английский
Процитировано
0
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июль 15, 2024
Abstract Identifying biomarkers able to discriminate individuals on different health trajectories is crucial understand the molecular basis of age-related morbidity. We investigated multi-omics signatures general and organ-specific morbidity, as well their interconnectivity. examined cross-sectional metabolome proteome data from 3,142 adults Cooperative Health Research in South Tyrol (CHRIS) study, an Alpine population study designed investigate how human biology, environment, lifestyle factors contribute people’s over time. had 174 metabolites 148 proteins quantified fasting serum plasma samples. used Cumulative Illness Rating Scale (CIRS) Comorbidity Index (CMI), which considers morbidity 14 organ systems, assess status (any vs. healthy). Omics-signatures for were identified using random forest (RF) classifiers. Linear regression models fitted directionality omics markers associations, identify related Next age, we 21 10 relevant predictors results confirmed associations serotonin glutamate be age-independent. Considering several jointly endocrine, cardiovascular, renal To conclude, circulating was a potential novel predictor overall
Язык: Английский
Процитировано
0
Journal of Fungi, Год журнала: 2024, Номер 10(9), С. 638 - 638
Опубликована: Сен. 6, 2024
Vulvovaginal candidiasis (VVC) affects up to 75% of women at least once during their lifetime, and 8% suffer from frequent recurrent episodes VVC (RVVC). A lack a protective host response underlies vaginal
Язык: Английский
Процитировано
0