Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 25, 2024

Abstract A diagnosis of epilepsy has significant consequences for an individual but is often challenging in clinical practice. Novel biomarkers are thus greatly needed. Here, we investigated how common genetic factors (epilepsy polygenic risk scores, [PRSs]) influence detailed longitudinal electronic health records (EHRs) > 700k Finns and Estonians. We found that a high generalized PRS (PRS GGE ) increased (GGE) (hazard ratio [HR] 1.73 per standard deviation [SD]) across lifetime within 10 years after unspecified seizure event. The effect was significantly larger on idiopathic epilepsies, females earlier onset. Analogously, more modest focal burden associated with non-acquired (NAFE). outline the potential specific PRSs to serve as first

Язык: Английский

Genetic Testing for Epilepsy: A User Guide

Current Treatment Options in Neurology, Год журнала: 2024, Номер 26(10), С. 441 - 449

Опубликована: Авг. 2, 2024

Язык: Английский