Escalation of intravenous fentanyl self-administration and assessment of withdrawal behavior in male and female mice DOI Creative Commons
Yueyi Chen, Tiange Xiao, Adam Kimbrough

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 5, 2024

Abstract Background The rise in overdose deaths from synthetic opioids, especially fentanyl, necessitates the development of preclinical models to study fentanyl use disorder (FUD). While there has been progress with rodent models, additional translationally relevant are needed examine excessive intake and withdrawal symptoms. Methods performed intravenous self-administration (IVSA) male female C57BL/6J mice for 14 days. Mechanical pain sensitivity during was assessed using von Frey test. Anxiety-like behavior evaluated via open field test one-week into abstinence incubation craving four weeks abstinence. Results Both demonstrated a significant escalation over days self-administration, front-loading observed final self-administration. Increased mechanical present 36- 48-hour increased anxiety-like found 1 week Four abstinence, showed significantly higher active lever pressing than session prior Conclusions establishes mouse model IVSA effectively encapsulating critical aspects FUD, including drug intake, behavior, symptoms, prolonged This offers robust basis further exploration behavioral neurobiological mechanisms involved dependence potential therapeutic strategies.

Язык: Английский

Escalation of intravenous fentanyl self-administration and assessment of withdrawal behavior in male and female mice DOI
Yueyi Chen, Tiange Xiao, Adam Kimbrough

и другие.

Psychopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 28, 2024

Язык: Английский

Процитировано

1
Escalation of intravenous fentanyl self-administration and assessment of withdrawal behavior in male and female mice DOI Creative Commons
Yueyi Chen, Tiange Xiao, Adam Kimbrough

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 5, 2024

Abstract Background The rise in overdose deaths from synthetic opioids, especially fentanyl, necessitates the development of preclinical models to study fentanyl use disorder (FUD). While there has been progress with rodent models, additional translationally relevant are needed examine excessive intake and withdrawal symptoms. Methods performed intravenous self-administration (IVSA) male female C57BL/6J mice for 14 days. Mechanical pain sensitivity during was assessed using von Frey test. Anxiety-like behavior evaluated via open field test one-week into abstinence incubation craving four weeks abstinence. Results Both demonstrated a significant escalation over days self-administration, front-loading observed final self-administration. Increased mechanical present 36- 48-hour increased anxiety-like found 1 week Four abstinence, showed significantly higher active lever pressing than session prior Conclusions establishes mouse model IVSA effectively encapsulating critical aspects FUD, including drug intake, behavior, symptoms, prolonged This offers robust basis further exploration behavioral neurobiological mechanisms involved dependence potential therapeutic strategies.

Язык: Английский

Процитировано

0