Communication subspace dynamics of the canonical olfactory pathway DOI Creative Commons
Joaqúın González, Pablo Torterolo, Kevin A. Bolding

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 10, 2024

Abstract Understanding how different brain areas communicate is crucial for elucidating the mechanisms underlying cognition. A possible way neural populations to interact through a communication subspace, specific region in state-space enabling transmission of behaviorally-relevant spiking patterns. In olfactory system, it remains unclear if employ such mechanism. Our study reveals that neuronal ensembles main pathway (olfactory bulb cortex) which driven by nasal respiration and allows feedforward feedback occur segregated along sniffing cycle. Moreover, our results demonstrate subspace depends causally on activity both areas, hindered during anesthesia, transmits low-dimensional representation odor.

Язык: Английский

A cellular basis for mapping behavioural structure DOI Creative Commons
Mohamady El-Gaby, Adam Harris, James C. R. Whittington

и другие.

Nature, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract To flexibly adapt to new situations, our brains must understand the regularities in world, as well those own patterns of behaviour. A wealth findings is beginning reveal algorithms that we use map outside world 1–6 . However, biological complex structured behaviours compose reach goals remain unknown. Here a neuronal implementation an algorithm for mapping abstract behavioural structure and transferring it scenarios. We trained mice on many tasks shared common (organizing sequence goals) but differed specific goal locations. The discovered underlying task structure, enabling zero-shot inferences first trial tasks. activity most neurons medial frontal cortex tiled progress goal, akin how place cells physical space. These ‘goal-progress cells’ generalized, stretching compressing their tiling accommodate different distances. By contrast, along overall was not encoded explicitly. Instead, subset goal-progress further tuned such individual fired with fixed lag from particular step. Together, these acted task-structured memory buffers, implementing instantaneously entire future steps, whose dynamics automatically computed appropriate action at each mirrored both on-task during offline sleep. Our suggest schemata structures can be generated by sculpting progress-to-goal tuning into buffers steps.

Язык: Английский

Процитировано

9
Cognitive neuroscience: How the brain navigates abstract task spaces DOI
Sina Tafazoli, Adel Ardalan, Timothy J. Buschman

и другие.

Current Biology, Год журнала: 2025, Номер 35(2), С. R60 - R62

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Compositional architecture: Orthogonal neural codes for task context and spatial memory in prefrontal cortex DOI Creative Commons
JeongJun Park, Charles D. Holmes, Lawrence H. Snyder

и другие.

Опубликована: Фев. 26, 2025

The prefrontal cortex (PFC) is crucial for maintaining working memory across diverse cognitive tasks, yet how it adapts to varying task demands remains unclear. Compositional theories propose that processes in neural network rely on shared components can be reused support different behaviors. However, previous studies have suggested are specific, challenging this framework. Here, we revisit question using a population-based approach. We recorded activity macaque monkeys performing two spatial tasks with opposing goals: one requiring movement toward previously presented locations (look task) and the other avoidance of those (no-look task). Despite differences demands, found representations were largely conserved at population level, common low-dimensional subspace encoding both tasks. In parallel, identity was encoded an orthogonal subspace, providing stable independent representation contextual information. These results provide evidence compositional model memory, where representational geometry enables efficient flexible reuse mnemonic codes behavioral contexts while context.

Язык: Английский

Процитировано

0
Episodic memory supports the acquisition of structured task representations DOI Creative Commons
Qihong Lu, Ali Hummos, Kenneth A. Norman

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 7, 2024

Abstract Generalization to new tasks requires learning of task representations that accurately reflect the similarity structure space. Here, we argue episodic memory (EM) plays an essential role in this process by stabilizing representations, thereby supporting accumulation structured knowledge. We demonstrate using a neural network model infers minimize current task’s objective function; crucially, can retrieve previously encoded from EM and use these initialize inference process. With EM, succeeds underlying structure; without drift fails learn structure. further show errors support promoting activation similar with sensory inputs. Overall, provides novel account how supports acquisition representations.

Язык: Английский

Процитировано

1
Practice Reshapes the Geometry and Dynamics of Task-tailored Representations DOI Creative Commons
Atsushi Kikumoto, Kazuhisa Shibata,

Takahiro Nishio

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 15, 2024

Extensive practice makes task performance more efficient and precise, leading to automaticity. However, theories of automaticity differ on which levels representations (e.g., low-level features, stimulus-response mappings, or high-level conjunctive memories individual events) change with practice, despite predicting the same pattern improvement power law practice). To resolve this controversy, we built recent theoretical advances in understanding computations through neural population dynamics. Specifically, hypothesized that optimizes representational geometry minimally separate highest-level contingencies needed for successful performance. This involves efficiently reaching states integrate task-critical features nonlinearly while abstracting over non-critical dimensions. test hypothesis, human participants (n = 40) engaged extensive a simple, context-dependent action selection 3 days recording EEG. During initial rapid performance, highest-level, context-specific conjunctions task-features were enhanced as function number episodes. Crucially, only enhancement these representations, not lower-order predicted power-law Simultaneously, sessions, became stable earlier time aligned, redundant correlated offline gain reducing switch costs. Thus, dynamic task-tailored tesselate space, taming their high-dimensionality.

Язык: Английский

Процитировано

1
Communication subspace dynamics of the canonical olfactory pathway DOI Creative Commons
Joaqúın González, Pablo Torterolo, Kevin A. Bolding

и другие.

iScience, Год журнала: 2024, Номер 27(12), С. 111275 - 111275

Опубликована: Окт. 30, 2024

Язык: Английский

Процитировано

1
Communication subspace dynamics of the canonical olfactory pathway DOI Creative Commons
Joaqúın González, Pablo Torterolo, Kevin A. Bolding

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 10, 2024

Abstract Understanding how different brain areas communicate is crucial for elucidating the mechanisms underlying cognition. A possible way neural populations to interact through a communication subspace, specific region in state-space enabling transmission of behaviorally-relevant spiking patterns. In olfactory system, it remains unclear if employ such mechanism. Our study reveals that neuronal ensembles main pathway (olfactory bulb cortex) which driven by nasal respiration and allows feedforward feedback occur segregated along sniffing cycle. Moreover, our results demonstrate subspace depends causally on activity both areas, hindered during anesthesia, transmits low-dimensional representation odor.

Язык: Английский

Процитировано

0