From HHV-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID. DOI
Michaël Maes, Abbas F. Almulla,

Xiaoou Tang

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 30, 2024

Abstract Background Inflammation and autoimmune responses contribute to the pathophysiology of Long COVID, its affective chronic fatigue syndrome (CFS) symptoms, labeled “the physio-affective phenome.” Objectives To investigate whether COVID phenome are linked autoimmunity tight junction proteins, zonulin occludin (ZOOC), immune reactivity lipopolysaccharides (LPS), latter associated with signs human herpes virus-6 reactivation (HHV-6), directed against oligodendrocyte neuronal including myelin basic protein (MBP). Methods IgA / IgM/IgG Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), HHV-6, ZOOC, C-reactive (CRP) advanced oxidation products (AOPP), were measured in 90 patients healthy controls. The was conceptualized as a factor extracted from physical symptom domains. Results Neural network identified LPS (IgA-LPS), IgG-ZOOC, IgG-LPS, IgA-ZOOC most important variables diagnosis an area under ROC curve 0.755. Partial Least Squares analysis showed that 40.9% variance explained by CRP, IgA-MPB IgG-MBP. A large part variances both MBP (36.3-39.7%) (IgA IgG) ZOOC. strongly indicants HHV-6 reactivation, which turn increased IgM-SARS-CoV-2. Conclusions Autoimmunity components junctions bacterial translocation may be involved COVID’s phenome.

Язык: Английский

From HHV-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID. DOI
Michaël Maes, Abbas F. Almulla,

Xiaoou Tang

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 30, 2024

Abstract Background Inflammation and autoimmune responses contribute to the pathophysiology of Long COVID, its affective chronic fatigue syndrome (CFS) symptoms, labeled “the physio-affective phenome.” Objectives To investigate whether COVID phenome are linked autoimmunity tight junction proteins, zonulin occludin (ZOOC), immune reactivity lipopolysaccharides (LPS), latter associated with signs human herpes virus-6 reactivation (HHV-6), directed against oligodendrocyte neuronal including myelin basic protein (MBP). Methods IgA / IgM/IgG Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), HHV-6, ZOOC, C-reactive (CRP) advanced oxidation products (AOPP), were measured in 90 patients healthy controls. The was conceptualized as a factor extracted from physical symptom domains. Results Neural network identified LPS (IgA-LPS), IgG-ZOOC, IgG-LPS, IgA-ZOOC most important variables diagnosis an area under ROC curve 0.755. Partial Least Squares analysis showed that 40.9% variance explained by CRP, IgA-MPB IgG-MBP. A large part variances both MBP (36.3-39.7%) (IgA IgG) ZOOC. strongly indicants HHV-6 reactivation, which turn increased IgM-SARS-CoV-2. Conclusions Autoimmunity components junctions bacterial translocation may be involved COVID’s phenome.

Язык: Английский

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