International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 9961 - 9961
Опубликована: Сен. 15, 2024
Understanding the pathogenesis and mechanisms of prion diseases can significantly expand our knowledge in field neurodegenerative diseases. Prion biology is increasingly recognized as being relevant to pathophysiology Alzheimer's disease Parkinson's disease, both which affect millions people each year. This bioinformatics study used a theoretical protein-RNA recognition code (1-L transcription) reveal post-transcriptional regulation protein (PrPC). The principle for this method directly elucidated on PrPC, an octa-repeat be 1-L transcribed into GGA triplet repeat RNA aptamer known reduce misfolding normal PrPC abnormal PrPSc. identified genes/proteins are associated with mitochondria, cancer, COVID-19 ER-stress, approximately half or indirectly For example, supports CD44, regions brain astrocytic accumulation also display high levels CD44.
Язык: Английский