Electrical Synapse Rectification Enables Dual-Network Activity in the crab Cancer borealis DOI Creative Commons
Savanna-Rae H. Fahoum, Farzan Nadim, Dawn M. Blitz

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 17, 2024

Flexibility of rhythmic networks includes neuromodulator-elicited changes in neuronal participation between networks. We are examining the role rectifying electrical synapses this switching. Electrical can have complex, non-intuitive effects on network output. However, it is often difficult to measure and manipulate rectification across conditions determine their functional contributions. Here, we use Jonah crab Cancer borealis investigate well-described In an established modulatory state, stimulating projection neuron MCN5 or bath applying its neuropeptide Gly1-SIFamide causes two LPG neurons switch from pyloric rhythm-only (food filtering, 1 Hz) activity dual gastric mill rhythm (chewing, 0.1 activity. Typically, co-active with PD single AB pacemaker due coupling. Gly1-SIFamide, continues burst time AB/PD but periodically escapes generates intrinsic longer-duration mill-timed bursts, decreasing overall synchrony AB/PD, while retain synchronous timing. Using two-electrode voltage clamp recordings, find that does not alter coupling strength AB/PD. a computational model, necessary for escape generate longer, bursts. This was confirmed biological system by adding dynamic non-rectifying synapse PD, which decreased Thus, electrically coupled oscillators underlie modulator-elicited synchrony.

Язык: Английский

Neuropeptide Modulation of Bidirectional Internetwork Synapses DOI
Savanna-Rae H. Fahoum, Dawn M. Blitz

Journal of Neurophysiology, Год журнала: 2024, Номер 132(1), С. 184 - 205

Опубликована: Май 22, 2024

Neuromodulation can enable neurons to simultaneously coordinate with separate networks. Both recruitment into, and coordination with, a second network occur via modulation of internetwork synapses. Alternatively, intrinsic ionic currents. We find that the same neuropeptide previously determined modulate currents also modulates bidirectional synapses are typically ineffective. Thus, complementary modulatory peptide actions neuron into network.

Язык: Английский

Процитировано

3
Electrical Synapse Rectification Enables Dual-Network Activity in the crab Cancer borealis DOI Creative Commons
Savanna-Rae H. Fahoum, Farzan Nadim, Dawn M. Blitz

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 17, 2024

Flexibility of rhythmic networks includes neuromodulator-elicited changes in neuronal participation between networks. We are examining the role rectifying electrical synapses this switching. Electrical can have complex, non-intuitive effects on network output. However, it is often difficult to measure and manipulate rectification across conditions determine their functional contributions. Here, we use Jonah crab Cancer borealis investigate well-described In an established modulatory state, stimulating projection neuron MCN5 or bath applying its neuropeptide Gly1-SIFamide causes two LPG neurons switch from pyloric rhythm-only (food filtering, 1 Hz) activity dual gastric mill rhythm (chewing, 0.1 activity. Typically, co-active with PD single AB pacemaker due coupling. Gly1-SIFamide, continues burst time AB/PD but periodically escapes generates intrinsic longer-duration mill-timed bursts, decreasing overall synchrony AB/PD, while retain synchronous timing. Using two-electrode voltage clamp recordings, find that does not alter coupling strength AB/PD. a computational model, necessary for escape generate longer, bursts. This was confirmed biological system by adding dynamic non-rectifying synapse PD, which decreased Thus, electrically coupled oscillators underlie modulator-elicited synchrony.

Язык: Английский

Процитировано

0