Lysosomal Quality Control
Autophagy,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Healthy
cells
need
functional
lysosomes
to
degrade
cargo
delivered
by
autophagy
and
endocytosis.
Defective
can
lead
severe
conditions
such
as
lysosomal
storage
diseases
(LSDs)
neurodegeneration.
To
maintain
lysosome
integrity
functionality,
have
evolved
multiple
quality
control
pathways
corresponding
different
types
of
stress
damage.
These
be
divided
into
five
levels:
regulation,
reformation,
repair,
removal,
replacement.
The
levels
often
work
together
the
network.
This
review
summarizes
discusses
less-studied
area
membrane
protein
regulation
degradation,
highlighting
key
unanswered
questions
in
field.
Язык: Английский
Lysosomes: guardians and healers within cells- multifaceted perspective and outlook from injury repair to disease treatment
Cancer Cell International,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 9, 2025
Lysosomes,
as
crucial
organelles
within
cells,
carry
out
diverse
biological
functions
such
waste
degradation,
regulation
of
the
cellular
environment,
and
precise
control
cell
signaling.
This
paper
reviews
core
structural
characteristics
lysosomes,
delves
into
current
research
status
lysosomes
damage
repair
mechanisms.
Subsequently,
we
explore
in
depth
close
association
between
various
diseases,
including
but
not
limited
to
age-related
chronic
neuro-degenerative
tumors,
inflammation,
immune
imbalance.
Additionally,
also
provide
a
detailed
discussion
application
lysosome-targeted
substances
field
regenerative
medicine,
especially
enormous
potential
demonstrated
key
areas
stem
therapy,
myocardial
repair.
Though
integration
multidisciplinary
efforts,
believe
that
mechanisms
will
demonstrate
even
greater
value
disease
treatment
medicine.
Язык: Английский
Stress Granules in Infectious Disease: Cellular Principles and Dynamic Roles in Immunity and Organelles
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12950 - 12950
Опубликована: Дек. 2, 2024
Stress
granules
(SGs)
are
membrane-less
aggregates
that
form
in
response
to
various
cellular
stimuli
through
a
process
called
liquid-liquid
phase
separation
(LLPS).
Stimuli
such
as
heat
shock,
osmotic
stress,
oxidative
and
infections
can
induce
the
formation
of
SGs,
which
play
crucial
roles
regulating
gene
expression
help
cells
adapt
stress
conditions.
Various
mRNAs
proteins
aggregated
into
particularly
those
associated
with
protein
translation
machinery,
frequently
found
SGs.
When
induced
by
infections,
SGs
modulate
immune
cell
activity,
supporting
against
infection.
The
differ
viral
versus
microbial
depending
on
type
involved,
function
differently
In
this
review,
we
summarize
our
current
understanding
implication
immunity
organelles
context
infectious
diseases.
Importantly,
explore
insights
regulatory
functions
host
under
Язык: Английский