Age- and sex-related changes in motor functions: a comprehensive assessment and component analysis
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Май 15, 2024
Age-related
motor
impairments
often
cause
caregiver
dependency
or
even
hospitalization.
However,
comprehensive
investigations
of
the
different
abilities
and
changes
thereof
across
adult
lifespan
remain
sparse.
We,
therefore,
extensively
assessed
essential
basic
complex
functions
in
444
healthy
adults
covering
a
wide
age
range
(range
21
to
88
years).
Basic
functions,
here
defined
as
simple
isolated
single
repetitive
movements
one
direction,
were
by
means
maximum
grip
strength
(GS)
finger-tapping
frequency
(FTF).
Complex
comprising
composite
sequential
involving
both
proximal
distal
joints/muscle
groups,
evaluated
with
Action
Research
Arm
Test
(ARAT),
Jebsen-Taylor
Hand
Function
(JTT),
Purdue
Pegboard
Test.
Men
achieved
higher
scores
than
women
concerning
GS
FTF,
whereas
stacked
more
pins
per
time
men
during
There
was
no
significant
sex
effect
regarding
JTT.
We
observed
but
task-specific
reduction
performance
lifespan.
Linear
regression
analyses
significantly
predicted
participants'
ages
based
on
(
Язык: Английский
Apraxic imitation deficits in Alzheimer's disease are associated with altered dynamic connectivity
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 6, 2024
Abstract
Apraxia
is
a
common
symptom
in
individuals
with
Alzheimer’s
disease
(AD).
However,
the
neural
mechanisms
underlying
apraxic
deficits
AD
remain
elusive.
Therefore,
current
study
focuses
on
association
between
altered
functional
connectivity
and
apraxia
examining
hypothesis
that
result
from
dysfunction
praxis-related
networks.
To
this
aim,
we
examined
changes
static
dynamic
(FC)
of
resting-state
networks
AD.
Resting-state
MRI
data
was
acquired
13
patients
tau-and
amyloid-positive
AD,
who
underwent
an
extensive
neuropsychological,
motor
assessment,
matched
healthy
control
participants.
The
resting
state
revealed
by
independent
component
analysis
(ICA)
were
assessed
measures
correlated
scores.
Across
all
participants,
identified
two
distinct
FC
states
using
sliding
window
approach.
Patients
exhibited
prolonged
dwell
times
first
characterized
weaker
spent
overall
more
time
state,
i.e.,
showed
increased
fraction
state.
Apraxic
deficits,
especially
imitating
gestures,
significantly
both
as
well
weakly
connected
Data
suggest
imitation
are
associated
praxis
FC.
Язык: Английский