Prognostic Value of PSMB5 and Correlations with LC3II and Reactive Oxygen Species Levels in the Bone Marrow Mononuclear Cells of Bortezomib-Resistant Multiple Myeloma Patients
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(1), С. 32 - 32
Опубликована: Янв. 6, 2025
Proteasome
inhibitors
(PIs)
constitute
the
most
common
type
of
induction
treatment
for
multiple
myeloma.
Interactions
between
proteasome,
autophagy,
and
reactive
oxygen
species
(ROS)
have
been
shown
in
past,
thus
emphasizing
need
a
better
understanding
underlying
pathophysiology.
For
this
study,
bone
marrow
mononuclear
cells
from
110
myeloma
patients
were
collected
at
different
disease
stages.
PSMB5
LC3I/II
protein
levels
determined
using
Western
blot,
proteasome
proteolytic
activity
(PPA)
with
spectrofluorometry,
ROS
flow
cytometry.
accumulation
was
found
to
diminish
after
PI
(p-value
=
0.014),
same
pattern
observed
PPA
<
0.001).
Conversely,
LC3II
elevated
both
remission
relapse
compared
baseline
0.041).
Patients
lower
than
1.06
units
had
longer
disease-free
survival
those
values
above
(12.0
±
6.7
vs.
36
12.1
months;
p-value
Median
plasma
significantly
higher
0.001),
implying
poor
prognosis.
Overall,
post-treatment
reduction
could
indicate
shift
proteasomal
autophagic
degradation
as
main
proteostatic
mechanism,
explaining
resistance.
The
oxidative
stress
PI-treated
possibly
serve
an
additional
compensatory
mechanism.
Язык: Английский
Therapy resistance in prostate cancer: mechanism, signaling and reversal strategies
Exploration of Targeted Anti-tumor Therapy,
Год журнала:
2024,
Номер
5(5), С. 1110 - 1134
Опубликована: Авг. 29, 2024
Prostate
cancer
(PC)
depicts
a
major
health
challenge
all
over
the
globe
due
to
its
complexities
in
treatment
and
diverse
clinical
trajectories.
Even
advances
modern
strategies,
spectrum
of
resistance
therapies
continues
be
significant
challenge.
This
review
comprehensively
examines
underlying
mechanisms
therapy
occurred
PC,
focusing
on
both
tumor
microenvironment
signaling
pathways
implicated
resistance.
Tumor
comprises
stromal
epithelial
cells,
which
influences
growth,
response
progression.
Mechanisms
such
as
microenvironmental
epithelial-mesenchymal
transition
(EMT),
anoikis
suppression
stimulation
angiogenesis
results
Moreover,
dysregulation
including
androgen
receptor
(AR),
mammalian
target
rapamycin/phosphoinositide
3
kinase/AKT
(mTOR/PI3K/AKT),
DNA
damage
repair
Janus
kinase/signal
transducers
activators
transcription
(JAK/STAT)
drive
by
promoting
survival
proliferation.
Understanding
these
molecular
is
important
for
developing
targeted
therapeutic
interventions
overcomes
In
conclusion,
complete
grasp
medication
PC
development
individualized
plans
enhancements
outcomes.
By
studying
understanding
complex
factors
contributing
resistance,
this
study
focuses
aims
guide
innovative
approaches
effectively
overcome
progression
improve
rate
patients.
Язык: Английский