Towards Practical Conservation Cloning: Understanding the Dichotomy Between the Histories of Commercial and Conservation Cloning DOI Creative Commons
Ben J. Novak,

Stewart Brand,

Ryan Phelan

и другие.

Animals, Год журнала: 2025, Номер 15(7), С. 989 - 989

Опубликована: Март 29, 2025

Over 40 years ago, scientists imagined ways cloning could aid conservation of threatened taxa. The Dolly the sheep from adult somatic cells in 1996 was breakthrough that finally enabled potential technology. Until 2020s, research efforts yielded no management applications, leading many to believe is not yet an effective tool. In strong contrast, domestic taxa are cloned routinely for scientific and commercial purposes. this review, we sought understand reasons these divergent trends. We scoured peer-reviewed gray literature sent direct inquiries analyze a more comprehensive history field than analyzed previous reviews. While most reviewers concluded lack reproductive knowledge wildlife species has hindered advances wider found resource limitations (e.g., numbers surrogates, sustainable funding) widely held misconceptions about significant contributors stagnation field. Recent successes programs endangered black-footed ferret (Mustela nigripes) Przewalski's horse (Equus przewalskii), world's first true applied-conservation efforts, demonstrating can be used impact present. When viewed alongside long achievements, emphasize value investing science resources needed meaningfully integrate into management, especially with limited genetic diversity rely on maintenance small populations generations while conservationists work restore habitat mitigate threats wild.

Язык: Английский

Endangered Przewalski’s Horse, Equus przewalskii, Cloned from Historically Cryopreserved Cells DOI Creative Commons
Ben J. Novak, Oliver A. Ryder, Marlys L. Houck

и другие.

Animals, Год журнала: 2025, Номер 15(5), С. 613 - 613

Опубликована: Фев. 20, 2025

Cloning from historically cryopreserved cells offers a potential means to restore lost genetic variation or increase the representation of particular lineages within bottlenecked species, provided such biobanked materials are archived for rescue applications. One species which cloning can provide management benefits is Przewalski's horse, Equus przewalskii. All ~1800 living horses, distributed across ex situ breeding facilities and in reintroduction sites, descended one more five founder established by 12 horses captured wild between 1898 1947. Since 1970s, San Diego Zoo Wildlife Alliance Biodiversity Bank's Frozen Zoo® (Escondido, CA, USA) has tissues 575 individuals spanning many generations. A pedigree analysis subset deceased represented revealed an underrepresented male that lived 1975 1998, Studbook Number 615 (also known as Kuporovitch), who would be high value if cloned. Here, we report two healthy clones were produced this cell line using cross-species somatic nuclear transfer 2020 2023. Their identification was verified standard horse-pedigree genotyping panel, and, clone, whole genome sequencing comparison original donor performed. This first time multiple surviving perinatal period have been endangered species.

Язык: Английский

Процитировано

1
Towards Practical Conservation Cloning: Understanding the Dichotomy Between the Histories of Commercial and Conservation Cloning DOI Creative Commons
Ben J. Novak,

Stewart Brand,

Ryan Phelan

и другие.

Animals, Год журнала: 2025, Номер 15(7), С. 989 - 989

Опубликована: Март 29, 2025

Over 40 years ago, scientists imagined ways cloning could aid conservation of threatened taxa. The Dolly the sheep from adult somatic cells in 1996 was breakthrough that finally enabled potential technology. Until 2020s, research efforts yielded no management applications, leading many to believe is not yet an effective tool. In strong contrast, domestic taxa are cloned routinely for scientific and commercial purposes. this review, we sought understand reasons these divergent trends. We scoured peer-reviewed gray literature sent direct inquiries analyze a more comprehensive history field than analyzed previous reviews. While most reviewers concluded lack reproductive knowledge wildlife species has hindered advances wider found resource limitations (e.g., numbers surrogates, sustainable funding) widely held misconceptions about significant contributors stagnation field. Recent successes programs endangered black-footed ferret (Mustela nigripes) Przewalski's horse (Equus przewalskii), world's first true applied-conservation efforts, demonstrating can be used impact present. When viewed alongside long achievements, emphasize value investing science resources needed meaningfully integrate into management, especially with limited genetic diversity rely on maintenance small populations generations while conservationists work restore habitat mitigate threats wild.

Язык: Английский

Процитировано

0