Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cell Reports Medicine,
Год журнала:
2025,
Номер
unknown, С. 101968 - 101968
Опубликована: Фев. 1, 2025
Highlights•Physical
activity
helps
protect
against
age-related
decline
in
physical
performance•Physical
boosts
mitochondrial
energetics
while
aging
per
se
has
no
impact•Mitochondrial
ROS
production
is
unaffected
by
both
active
and
inactive
men•Mitochondrial
calcium
handling
declines
with
age
linked
to
muscle
performanceSummaryAging-related
atrophy
weakness
contribute
loss
of
mobility,
falls,
disability.
Mitochondrial
dysfunction
widely
considered
a
key
contributing
mechanism
aging.
However,
mounting
evidence
positions
as
confounding
factor,
making
unclear
whether
mitochondria
accumulate
bona
fide
defects
To
disentangle
from
activity-related
adaptations,
we
functionally
profiled
skeletal
51
88
men
aged
20–93.
Physical
status
confers
partial
protection
performance.
respiration
remains
unaltered
participants,
indicating
that
does
not
alter
respiratory
capacity.
reactive
oxygen
species
(ROS)
higher
participants.
In
contrast,
retention
capacity
decreases
regardless
correlates
mass,
performance,
the
stress-responsive
metabokine/mitokine
growth
differentiation
factor
15
(GDF15).
Targeting
may
hold
promise
for
treating
aging-related
impairments.Graphical
abstract
Язык: Английский
Biopsychosocial Correlates of Resting and Stress-Reactive Salivary GDF15: Preliminary Findings
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Growth
differentiation
factor
15
(GDF15)
is
a
biomarker
of
energetic
stress
related
to
aging,
disease,
and
mitochondrial
defects.
We
recently
showed
that
GDF15
quantifiable
in
saliva
acutely
inducible
by
psychosocial
stress.
To
date,
the
associations
between
biopsychosocial
factors
individual
characteristics
remain
unknown.
Here,
sample
healthy
working
adults
(
n
=
198,
70%
females),
we
first
confirmed
salivary
reacts
acute
stress,
peaking
10
min
following
socio-evaluative
paradigm
(+28.3%,
g
0.50,
p
<
0.0001).
then
explored
i)
baseline
ii)
reactivity
variety
trait-
state-level
including
sex
gender
characteristics;
measures
mental
health,
burnout;
physical
health
behaviors;
anthropometric
blood-based
metabolic
biomarkers.
Baseline
was
higher
men
than
women
positively
correlated
with
testosterone,
while
negatively
estrogen
traditionally
feminine
roles.
Of
examined,
found
work-related
variables
were
most
consistently
GDF15,
cynicism,
burnout,
emotional
exhaustion
predicting
reactivity,
job-related
autonomy
utilization
competence
predicted
smaller
responses.
Consistent
GDF15's
induction
renal
diseases,
also
indirect
markers
disease
waist-to-hip
ratio,
creatinine,
albumin.
Finally,
participants
greater
exhibited
cortisol
consistent
role
regulation
energy
mobilization.
Together,
this
exploratory
analysis
suggest
new
biological
correlates,
calling
for
large-scale
studies
connecting
human
experiences
Язык: Английский
Impact of physical activity on physical performance, mitochondrial bioenergetics, ROS production and calcium handling across the human adult lifespan
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 13, 2024
Aging-related
muscle
atrophy
and
weakness
contribute
to
loss
of
mobility,
falls
disability.
Mitochondrial
dysfunction
is
widely
considered
a
key
contributing
mechanism
aging.
However,
mounting
evidence
position
physical
activity
as
confounding
factor,
making
unclear
whether
mitochondria
accumulate
bona
fide
defects
with
To
disentangle
aging
from
activity-related
mitochondrial
adaptations,
we
functionally
profiled
skeletal
in
51
inactive
88
active
men
aged
20-93.
Physical
status
conferred
partial
protection
against
age-related
decline
performance.
A
trend
for
reduced
respiration
was
observed
but
not
participants,
indicating
that
per
se
does
alter
respiratory
capacity.
reactive
oxygen
species
(ROS)
production
unaffected
by
participants
displayed
higher
ROS
production.
In
contrast,
calcium
retention
capacity
decreased
regardless
correlated
mass,
performance
the
stress-responsive
metabokine
GDF15.
Targeting
handling
may
hold
promise
treating
aging-related
impairments.
Язык: Английский
Associations between prenatal distress, mitochondrial health, and gestational age: findings from two pregnancy studies in the USA and Turkey
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 16, 2024
Pregnancy
outcomes
are
influenced
by
maternal
distress
but
the
pathways
underlying
these
effects
still
unknown.
Mitochondria,
crucial
for
stress
adaptation
and
energy
production,
may
link
psychosocial
to
its
biological
effects,
especially
during
pregnancy
when
demands
significantly
increase.
This
study
explores
two
mitochondrial
markers-circulating
cell-free
DNA
(cf-mtDNA)
Growth
Differentiation
Factor-15
(GDF15)-as
potential
health
indicators
linking
in
longitudinal
studies
from
USA
Turkey.
Язык: Английский