A neural circuit for context-dependent multimodal signaling inDrosophila DOI Creative Commons
Elsa Steinfath,

Afshin Khalili,

Melanie Stenger

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 7, 2024

Abstract Many animals, including humans, produce multimodal displays by combining acoustic with visual or vibratory signals [1–4]. However, the neural circuits that coordinate production of multiple in a context-dependent manner are unknown. Multimodal behaviors could be produced parallel independently integrate external cues trigger each signal. We find Drosophila driven single circuit integrates sensory internal motivational state and dynamics. males air-borne song substrate-borne vibration during courtship previous studies have identified neurons drive singing, but contexts vibrations signaling were not known [5–11]. show distinct, largely non-overlapping brain also cell-type specific dynamics via separate pre-motor pathways. This coordinates ongoing behavior, namely locomotion, to only when male’s can reach female. A shared facilitates control signal through mechanisms like recurrence mutual inhibition. proof-of-concept model shows these motifs sufficient explain behavioral Our work how simple combined select behaviors.

Язык: Английский

Comparative connectomics of the descending and ascending neurons of theDrosophilanervous system: stereotypy and sexual dimorphism DOI Creative Commons
Tomke Stürner, P. D. Brooks, Laia Serratosa Capdevila

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 6, 2024

In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains of final motor outputs necessary for behaviour, and brain. insects, neck connective both physical information bottleneck connecting brain ventral cord (VNC, spinal analogue) comprises diverse populations descending (DN), ascending (AN) sensory neurons, are crucial sensorimotor signalling control. Integrating three separate EM datasets, we now provide complete connectomic description neurons female system

Язык: Английский

Процитировано

12
Exploring the influence of a 10-week specific detraining on injury risk factors among elite young wrestlers: a prospective study DOI Creative Commons

Mahvash Noorbakhsh,

Mostafa Zarei, Fariborz Hovanloo

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 1, 2025

Extended periods of inactivity in sports can impact athletes' performance and overall well-being. The current study examined the effects a 10-week wrestling -specific detraining period on isokinetic strength knee shoulder flexor extensor muscles, proprioception, dynamic balance among young male elite wrestlers. This prospective included 63 wrestlers : age (19.33 ± 3 years), height (174.32 6.8 cm), weight (80.21 22.01 kg), BMI (25.34 5.89), fat percentage (13.25 5.80) Tehran's premier league. Baseline measurements, including flexors extensors, balance, were evaluated using Biodex 4 dynamometer meter, respectively, repeated after lockdown during COVID-19 pandemic at Shahid Beheshti University, Tehran, Iran. Statistical analysis utilized dependent t-tests to compare results. Significant differences observed muscles angular speeds 60, 180, 300 degrees per second 10 weeks (p < 0.05). Additionally, decrease accuracy joint proprioception was found, active angle restoration angles 30°, 60°, 90° passive movement detection flexion extension 90-degree Moreover, significantly reduced single-leg form findings revealed that affect musculoskeletal proprioceptive parameters wrestlers, increasing risk injuries reducing physical fitness. Consistent engagement training is essential ensure optimal fitness well-being, particularly for athletes.

Язык: Английский

Процитировано

0
Inhibitory circuits coordinate leg movements duringDrosophilagrooming DOI Creative Commons
Durafshan Sakeena Syed, Primoz Ravbar, J. Simpson

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 6, 2024

Limbs execute diverse actions coordinated by the nervous system through multiple motor programs. The basic architecture of neurons that activate muscles articulate joints for antagonistic flexion and extension movements is conserved from flies to vertebrates. While excitatory premotor circuits are expected establish sets leg work together, our study uncovered a new instructive role inhibitory circuits: their ability generate rhythmic movements. Using electron microscopy data Drosophila nerve cord, we categorized ~120 GABAergic 13A 13B hemi-lineages into classes based on similarities in morphology connectivity. By mapping synaptic partners, pathways inhibiting specific groups neurons, disinhibiting counterparts, inducing alternation between extension. We tested function optogenetic activation silencing, using an in-depth ethological analysis during grooming. combined anatomy behavior findings construct computational model can reproduce major aspects observed behavior, confirming sufficiency these rhythms.

Язык: Английский

Процитировано

1
A neural circuit for context-dependent multimodal signaling inDrosophila DOI Creative Commons
Elsa Steinfath,

Afshin Khalili,

Melanie Stenger

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 7, 2024

Abstract Many animals, including humans, produce multimodal displays by combining acoustic with visual or vibratory signals [1–4]. However, the neural circuits that coordinate production of multiple in a context-dependent manner are unknown. Multimodal behaviors could be produced parallel independently integrate external cues trigger each signal. We find Drosophila driven single circuit integrates sensory internal motivational state and dynamics. males air-borne song substrate-borne vibration during courtship previous studies have identified neurons drive singing, but contexts vibrations signaling were not known [5–11]. show distinct, largely non-overlapping brain also cell-type specific dynamics via separate pre-motor pathways. This coordinates ongoing behavior, namely locomotion, to only when male’s can reach female. A shared facilitates control signal through mechanisms like recurrence mutual inhibition. proof-of-concept model shows these motifs sufficient explain behavioral Our work how simple combined select behaviors.

Язык: Английский

Процитировано

0