Deep brain stimulation-entrained gamma oscillations in chronic home recordings in Parkinson’s disease

Brain stimulation, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Highlights•Cortical gamma oscillations often entrain with pallidal and subthalamic stimulation•Entraining levodopa-induced diminishes their prodyskinetic effect•Levodopa-induced oscillation peak frequency variance reduces when entrainedAbstractBackgroundIn Parkinson's disease, invasive brain recordings show that dopaminergic medication can induce narrowband rhythms in the motor cortex nucleus, which co-fluctuate dyskinesia scores. Deep stimulation these to a subharmonic frequency. However, incidence of entrainment during chronic therapeutic stimulation, its relationship basal ganglia site, effect on remain unknown.ObjectiveDetermine whether behavioral effects statistical properties are altered entrained deep stimulation.MethodsWe used sensing-enabled stimulator system, attached both (n=15) or (n=5) leads, record 993 hours multisite field potentials, 656 recorded prior initiating stimulation. 13 subjects (20 hemispheres) disease (1/13 female, mean age 59±9 years) streamed data while at home usual antiparkinsonian medication. Recordings occurred least five months after stimulation.ResultsCortical were detected 4/5 hemispheres undergoing 12/15 Entraining either site reduced effects. Cortical had frequency, increased spectral power, higher power than oscillations.ConclusionStimulation-entrained functionally physiologically distinct from occur absence Understanding discrepancies between types may improve programming protocols.

Язык: Английский

Differential Responses to Low- and High-Frequency Subthalamic Nucleus Deep Brain Stimulation on Sensor-Measured Components of Bradykinesia in Parkinson’s Disease

Sensors, Год журнала: 2024, Номер 24(13), С. 4296 - 4296

Опубликована: Июль 2, 2024

The current approach to assessing bradykinesia in Parkinson's Disease relies on the Unified Rating Scale (UPDRS), which is a numeric scale. Inertial sensors offer ability probe subcomponents of bradykinesia: motor speed, amplitude, and rhythm. Thus, we sought investigate differential effects high-frequency compared low-frequency subthalamic nucleus (STN) deep brain stimulation (DBS) these quantified facets bradykinesia.

Язык: Английский