Projections from thalamic nucleus reuniens to hippocampal CA1 area participate in context fear extinction by affecting extinction-induced molecular remodeling of excitatory synapses
eLife,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 23, 2025
The
ability
to
extinguish
contextual
fear
in
a
changing
environment
is
crucial
for
animal
survival.
Recent
data
support
the
role
of
thalamic
nucleus
reuniens
(RE)
and
its
projections
dorsal
hippocampal
CA1
area
(RE→dCA1)
this
process.
However,
it
remains
poorly
understood
how
RE
impacts
dCA1
neurons
during
extinction
(CFE).
Here,
we
reveal
that
RE→dCA1
pathway
contributes
by
affecting
CFE-induced
molecular
remodeling
excitatory
synapses.
Anatomical
tracing
chemogenetic
manipulation
mice
demonstrate
form
synapses
regulate
synaptic
transmission
stratum
oriens
(SO)
lacunosum-moleculare
(SLM)
area,
but
not
radiatum
(SR).
We
also
observe
CFE-specific
structural
changes
expression
scaffold
protein,
PSD-95,
both
strata
innervated
RE,
SR.
Interestingly,
only
SLM
are
specific
dendrites
RE.
To
further
projection
CFE,
brief
inhibition
CFE
session
persistently
impairs
formation
memory
PSD-95
levels
SLM.
Thus,
our
indicate
participates
regulating
Язык: Английский
Projections from thalamic nucleus reuniens to hippocampal CA1 area participate in context fear extinction by affecting extinction-induced molecular remodeling of excitatory synapses
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 31, 2024
Abstract
The
ability
to
extinguish
contextual
fear
in
a
changing
environment
is
crucial
for
animal
survival.
Recent
data
support
the
role
of
thalamic
nucleus
reuniens
(RE)
and
its
projections
dorsal
hippocampal
CA1
area
(RE→dCA1)
this
process.
However,
it
remains
poorly
understood
how
RE
impacts
dCA1
neurons
during
extinction
(CFE).
Here,
we
reveal
that
RE→dCA1
pathway
contributes
by
affecting
CFE-induced
molecular
remodeling
excitatory
synapses.
Anatomical
tracing
chemogenetic
manipulation
mice
demonstrate
form
synapses
regulate
synaptic
transmission
stratum
oriens
(SO)
lacunosum-moleculare
(SLM)
area,
but
not
radiatum
(SR).
We
also
observe
CFE-specific
structural
changes
expression
scaffold
protein,
PSD-95,
both
strata
innervated
RE,
SR.
Interestingly,
only
SLM
are
specific
dendrites
RE.
To
further
projection
CFE,
brief
inhibition
CFE
session
persistently
impairs
formation
memory
PSD-95
levels
SLM.
Thus,
our
indicate
participates
regulating
Язык: Английский
Projections from thalamic nucleus reuniens to hippocampal CA1 area participate in context fear extinction by affecting extinction-induced molecular remodeling of excitatory synapses
eLife,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 8, 2024
The
ability
to
extinguish
contextual
fear
in
a
changing
environment
is
crucial
for
animal
survival.
Recent
data
support
the
role
of
thalamic
nucleus
reuniens
(RE)
and
its
projections
dorsal
hippocampal
CA1
area
(RE→dCA1)
this
process.
However,
it
remains
poorly
understood
how
RE
impacts
dCA1
neurons
during
extinction
(CFE).
Here,
we
reveal
that
RE→dCA1
pathway
contributes
by
affecting
CFE-induced
molecular
remodeling
excitatory
synapses.
Anatomical
tracing
chemogenetic
manipulation
mice
demonstrate
form
synapses
regulate
synaptic
transmission
stratum
oriens
(SO)
lacunosum-moleculare
(SLM)
area,
but
not
radiatum
(SR).
We
also
observe
CFE-specific
structural
changes
expression
scaffold
protein,
PSD-95,
both
strata
innervated
RE,
SR.
Interestingly,
only
SLM
are
specific
dendrites
RE.
To
further
projection
CFE,
brief
inhibition
CFE
session
persistently
impairs
formation
memory
PSD-95
levels
SLM.
Thus,
our
indicate
participates
regulating
Язык: Английский
Projections from thalamic nucleus reuniens to hippocampal CA1 area participate in context fear extinction by affecting extinction-induced molecular remodeling of excitatory synapses
Опубликована: Окт. 8, 2024
The
ability
to
extinguish
contextual
fear
in
a
changing
environment
is
crucial
for
animal
survival.
Recent
data
support
the
role
of
thalamic
nucleus
reuniens
(RE)
and
its
projections
dorsal
hippocampal
CA1
area
(RE→dCA1)
this
process.
However,
it
remains
poorly
understood
how
RE
impacts
dCA1
neurons
during
extinction
(CFE).
Here,
we
reveal
that
RE→dCA1
pathway
contributes
consolidation
CFE
memory
by
affecting
CFE-induced
molecular
remodeling
excitatory
synapses.
Anatomical
tracing
chemogenetic
manipulation
mice
demonstrate
form
synapses
regulate
synaptic
transmission
stratum
oriens
(SO)
lacunosum-moleculare
(SLM)
area,
but
not
radiatum
(SR).
We
also
observe
CFE-specific
structural
changes
expression
scaffold
protein,
PSD-95,
both
strata
innervated
RE,
SR.
Interestingly,
only
SLM
are
specific
dendrites
RE.
To
further
projection
CFE,
brief
inhibition
session
persistently
impairs
formation
PSD-95
levels
SLM.
Thus,
our
indicate
participates
regulating
Язык: Английский
Projections from thalamic nucleus reuniens to hippocampal CA1 area participate in context fear extinction by affecting extinction-induced molecular remodeling of excitatory synapses
Опубликована: Дек. 27, 2024
The
ability
to
extinguish
contextual
fear
in
a
changing
environment
is
crucial
for
animal
survival.
Recent
data
support
the
role
of
thalamic
nucleus
reuniens
(RE)
and
its
projections
dorsal
hippocampal
CA1
area
(RE→dCA1)
this
process.
However,
it
remains
poorly
understood
how
RE
impacts
dCA1
neurons
during
extinction
(CFE).
Here,
we
reveal
that
RE→dCA1
pathway
contributes
by
affecting
CFE-induced
molecular
remodeling
excitatory
synapses.
Anatomical
tracing
chemogenetic
manipulation
mice
demonstrate
form
synapses
regulate
synaptic
transmission
stratum
oriens
(SO)
lacunosum-moleculare
(SLM)
area,
but
not
radiatum
(SR).
We
also
observe
CFE-specific
structural
changes
expression
scaffold
protein,
PSD-95,
both
strata
innervated
RE,
SR.
Interestingly,
only
SLM
are
specific
dendrites
RE.
To
further
projection
CFE,
brief
inhibition
CFE
session
persistently
impairs
formation
memory
PSD-95
levels
SLM.
Thus,
our
indicate
participates
regulating
Язык: Английский