Autoimmune liver diseases and systemic rheumatic disorders: exploring their interplay and impact on prognosis DOI Creative Commons

Mohammad Egbaria,

Amir Bieber, Ahmad Mahamid

и другие.

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 22, 2025

Autoimmune liver diseases (AILDs) are associated with systemic rheumatic (SRDs) and their autoantibodies. This study investigates the prevalence of SRDs related autoantibodies in AILD patients prognostic implications. We retrospectively analyzed all followed at Emek Medical Center's Hepatology Clinic for Patients were divided into two groups: vs. without Clinical course, outcomes, parameters compared between these groups. Among 157 patients, present 16.8%, detected 40.8%. both exhibited significantly higher frequencies anti-dsDNA (p = 0.005), anti-RNP < 0.001), APLA 0.004), RF 0.02), anti-Ro 0.001). Notably, had a rate transplantation to those (8% 0%, p 0.036). However, no significant differences overall prognosis or outcomes observed SRDs. highly prevalent patients. The presence specific autoantibodies, particularly anti-dsDNA, anti-RNP, may indicate an association could have value progression. Further studies needed validate findings explore clinical

Язык: Английский

Autoimmune liver diseases and systemic rheumatic disorders: exploring their interplay and impact on prognosis DOI Creative Commons

Mohammad Egbaria,

Amir Bieber, Ahmad Mahamid

и другие.

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 22, 2025

Autoimmune liver diseases (AILDs) are associated with systemic rheumatic (SRDs) and their autoantibodies. This study investigates the prevalence of SRDs related autoantibodies in AILD patients prognostic implications. We retrospectively analyzed all followed at Emek Medical Center's Hepatology Clinic for Patients were divided into two groups: vs. without Clinical course, outcomes, parameters compared between these groups. Among 157 patients, present 16.8%, detected 40.8%. both exhibited significantly higher frequencies anti-dsDNA (p = 0.005), anti-RNP < 0.001), APLA 0.004), RF 0.02), anti-Ro 0.001). Notably, had a rate transplantation to those (8% 0%, p 0.036). However, no significant differences overall prognosis or outcomes observed SRDs. highly prevalent patients. The presence specific autoantibodies, particularly anti-dsDNA, anti-RNP, may indicate an association could have value progression. Further studies needed validate findings explore clinical

Язык: Английский

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