Modelling how lamellipodia-driven cells maintain persistent migration and interact with external barriers DOI
Shubhadeep Sadhukhan, Cristina Martinez-Torres,

Samo Penič

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 7, 2024

Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow universal law that connects their speed persistency, property can originate from the intracellular transport polarity cues due global actin retrograde flow. This mechanism was termed “Universal Coupling between Speed Persistency”(UCSP). Here we implemented simplified version UCSP in coarse-grained “minimal-cell” model, which composed three-dimensional vesicle contains curved active proteins. model spontaneously forms lamellipodia-like shape, however sensitive depolarize into non-motile form random fluctuations or when interacting with external obstacles. The implementation introduces long-range inhibition, stabilizes phenotype. allows our describe robust observed explain large cellular dynamics, such as relation aspect ratio, cell-barrier scattering, oscillations different geometric confinements. Significance Statement membrane proteins protrusive forces arise recruited polymerization, lead, presence adhesion, self-organization leading-edge cluster “minimal-cell”. However, this polarized shape become unstable, interactions perturbations transform an immotile, symmetric shape. couple spatial organization advection cue along cell’s activity axis. Introducing resultant gradient polarity-cue motile, vesicle. We thereby present shape-migration relations, scattering spontaneous confined cells.

Язык: Английский

Modeling how lamellipodia-driven cells maintain persistent migration and interact with external barriers DOI Creative Commons
Shubhadeep Sadhukhan, Cristina Martinez-Torres,

Samo Penič

и другие.

Physical Review Research, Год журнала: 2025, Номер 7(1)

Опубликована: Март 27, 2025

Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow universal law that connects their speed persistency, property can originate from the intracellular transport polarity cues due global actin retrograde flow. This mechanism was termed “Universal Coupling between Speed Persistency”(UCSP). Here we implement simplified version UCSP in coarse-grained “minimal-cell” model, which composed three-dimensional vesicle contains curved active proteins. model spontaneously forms lamellipodia-like shape, is, however, sensitive depolarize into nonmotile form random fluctuations or when interacting with external obstacles. The implementation introduces long-range inhibition, stabilizes phenotype. allows our describe robust observed explain large cellular dynamics, such as relation aspect ratio, cell-barrier scattering, oscillations different geometric confinements. Published by American Physical Society 2025

Язык: Английский

Процитировано

0
Dynamic Plasma Membrane Topography Linked With Arp2/3 Actin Network Induction During Cell Shape Change DOI Creative Commons
Tony Harris

BioEssays, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

ABSTRACT Recent studies show the importance of mesoscale changes to plasma membrane (PM) topography during cell shape change. Local folding and flattening surface is mechanosensitive, changing in response both microenvironment structural elements intracellular cytoskeletal activities. These elicit local mechanical signaling events that act conjunction with molecular signal transduction pathways remodel cortex. Experimental manipulations PM curvature its sufficiency for recruiting Arp2/3 actin network induction pathways. Additionally, diverse changes—ranging from neutrophil migration early Drosophila embryo cleavage neural stem asymmetric division—show generation linked induction, which then remodels dynamic control structure. examples are reviewed detail, together known potential causes changes, downstream effects, higher‐order feedback.

Язык: Английский

Процитировано

0
Modelling how lamellipodia-driven cells maintain persistent migration and interact with external barriers DOI
Shubhadeep Sadhukhan, Cristina Martinez-Torres,

Samo Penič

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 7, 2024

Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow universal law that connects their speed persistency, property can originate from the intracellular transport polarity cues due global actin retrograde flow. This mechanism was termed “Universal Coupling between Speed Persistency”(UCSP). Here we implemented simplified version UCSP in coarse-grained “minimal-cell” model, which composed three-dimensional vesicle contains curved active proteins. model spontaneously forms lamellipodia-like shape, however sensitive depolarize into non-motile form random fluctuations or when interacting with external obstacles. The implementation introduces long-range inhibition, stabilizes phenotype. allows our describe robust observed explain large cellular dynamics, such as relation aspect ratio, cell-barrier scattering, oscillations different geometric confinements. Significance Statement membrane proteins protrusive forces arise recruited polymerization, lead, presence adhesion, self-organization leading-edge cluster “minimal-cell”. However, this polarized shape become unstable, interactions perturbations transform an immotile, symmetric shape. couple spatial organization advection cue along cell’s activity axis. Introducing resultant gradient polarity-cue motile, vesicle. We thereby present shape-migration relations, scattering spontaneous confined cells.

Язык: Английский

Процитировано

0