Are we cultivating the perfect storm for a human avian influenza pandemic? DOI Creative Commons
Tomás Pérez‐Acle, César Ravello, Mario Rosemblatt

и другие.

Biological Research, Год журнала: 2024, Номер 57(1)

Опубликована: Дек. 19, 2024

Abstract The emergence of highly pathogenic avian influenza (HPAI) A H5N1 virus in dairy cattle marks a troubling new chapter the ongoing battle against zoonotic diseases. Since its initial detection 1955, has primarily been associated with poultry, posing significant threats to both animal and human health. However, recent outbreaks U.S. herds across nine states have revealed an alarming expansion virus, over 190 affected as September 2024. This unprecedented spread sparked intense concern among scientists health officials, especially reports indicating that up 20% products may contain traces virus. implications establishing itself populations are profound. potential endemic presence could transform farms into reservoirs facilitating evolution increasing risk transmission. Mutations enhancing viral replication mammals already identified, including notorious PB2 E627K mutation linked increased virulence. Moreover, central nervous system infected animals, cats, underscores broad tissue tropism severe Current containment efforts include stringent biosecurity measures financial incentives for enhanced testing personal protective equipment (PPE) farmers. Yet, gaps infrastructure resurgence raw milk consumption pose challenges. Department Agriculture (USDA) Centers Disease Control Prevention (CDC) emphasize critical need comprehensive pasteurization mitigate infection. As scientific community races adapt existing antiviral treatments develop effective vaccines, concept One Health approach becomes increasingly vital. holistic strategy calls coordinated actions human, animal, environmental sectors preemptively tackle emerging threats. Strengthening surveillance, fostering international cooperation, investing research essential steps prevent from igniting next global crisis. current outbreak serves stark reminder delicate balance between activities evolution. Our collective ability respond effectively proactively will determine whether we can avert perfect storm brewing on horizon.

Язык: Английский

Environmental Dissemination of SARS-CoV-2: An Analysis Employing Crassphage and Next-Generation Sequencing Protocols DOI
André Vinicius Costa Ribeiro, Camille Ferreira Mannarino, Tiago Leal

и другие.

Food and Environmental Virology, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 7, 2025

Язык: Английский

Процитировано

0
Are we cultivating the perfect storm for a human avian influenza pandemic? DOI Creative Commons
Tomás Pérez‐Acle, César Ravello, Mario Rosemblatt

и другие.

Biological Research, Год журнала: 2024, Номер 57(1)

Опубликована: Дек. 19, 2024

Abstract The emergence of highly pathogenic avian influenza (HPAI) A H5N1 virus in dairy cattle marks a troubling new chapter the ongoing battle against zoonotic diseases. Since its initial detection 1955, has primarily been associated with poultry, posing significant threats to both animal and human health. However, recent outbreaks U.S. herds across nine states have revealed an alarming expansion virus, over 190 affected as September 2024. This unprecedented spread sparked intense concern among scientists health officials, especially reports indicating that up 20% products may contain traces virus. implications establishing itself populations are profound. potential endemic presence could transform farms into reservoirs facilitating evolution increasing risk transmission. Mutations enhancing viral replication mammals already identified, including notorious PB2 E627K mutation linked increased virulence. Moreover, central nervous system infected animals, cats, underscores broad tissue tropism severe Current containment efforts include stringent biosecurity measures financial incentives for enhanced testing personal protective equipment (PPE) farmers. Yet, gaps infrastructure resurgence raw milk consumption pose challenges. Department Agriculture (USDA) Centers Disease Control Prevention (CDC) emphasize critical need comprehensive pasteurization mitigate infection. As scientific community races adapt existing antiviral treatments develop effective vaccines, concept One Health approach becomes increasingly vital. holistic strategy calls coordinated actions human, animal, environmental sectors preemptively tackle emerging threats. Strengthening surveillance, fostering international cooperation, investing research essential steps prevent from igniting next global crisis. current outbreak serves stark reminder delicate balance between activities evolution. Our collective ability respond effectively proactively will determine whether we can avert perfect storm brewing on horizon.

Язык: Английский

Процитировано

2