MirGeneDB 3.0: improved taxonomic sampling, uniform nomenclature of novel conserved microRNA families and updated covariance models DOI Creative Commons

Alexander W. Clarke,

Eirik Høye, Anju Angelina Hembrom

и другие.

Nucleic Acids Research, Год журнала: 2024, Номер 53(D1), С. D116 - D128

Опубликована: Ноя. 30, 2024

Abstract We present a major update of MirGeneDB (3.0), the manually curated animal microRNA gene database. Beyond moving to new server and creation computational mirror, we have expanded database with addition 33 invertebrate species, including representatives 5 previously unsampled phyla, 6 mammal species. now contains entries for 21 822 genes (5160 these from species) belonging 1743 families. The inclusion species allowed us refine both evolutionary node appearance number genes/families, as well MirGeneDB’s phylogenetically informed nomenclature system. Updated covariance models all families, along smallRNA read data are downloadable. These enhanced annotations will allow researchers analyze properties such secondary structure features their biogenesis within robust phylogenetic context without plagued numerous false positives negatives. In light improvements, 3.0 assume responsibility naming conserved novel metazoan microRNAs. is part RNAcentral Elixir Norway publicly freely available at mirgenedb.org.

Язык: Английский

MirGeneDB 3.0: improved taxonomic sampling, uniform nomenclature of novel conserved microRNA families and updated covariance models DOI Creative Commons

Alexander W. Clarke,

Eirik Høye, Anju Angelina Hembrom

и другие.

Nucleic Acids Research, Год журнала: 2024, Номер 53(D1), С. D116 - D128

Опубликована: Ноя. 30, 2024

Abstract We present a major update of MirGeneDB (3.0), the manually curated animal microRNA gene database. Beyond moving to new server and creation computational mirror, we have expanded database with addition 33 invertebrate species, including representatives 5 previously unsampled phyla, 6 mammal species. now contains entries for 21 822 genes (5160 these from species) belonging 1743 families. The inclusion species allowed us refine both evolutionary node appearance number genes/families, as well MirGeneDB’s phylogenetically informed nomenclature system. Updated covariance models all families, along smallRNA read data are downloadable. These enhanced annotations will allow researchers analyze properties such secondary structure features their biogenesis within robust phylogenetic context without plagued numerous false positives negatives. In light improvements, 3.0 assume responsibility naming conserved novel metazoan microRNAs. is part RNAcentral Elixir Norway publicly freely available at mirgenedb.org.

Язык: Английский

Процитировано

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