Astrocyte-Secreted Lcn2 Modulates Dendritic Spine Morphology DOI Creative Commons
Marta Doliwa, Bożena Kuźniewska, Karolina Nader

и другие.

Cells, Год журнала: 2025, Номер 14(3), С. 159 - 159

Опубликована: Янв. 21, 2025

Learning and memory formation rely on synaptic plasticity, the process that changes strength in response to neuronal activity. In tripartite synapse concept, molecular signals affect morphology originate not only from pre- post-synaptic terminals but also astrocytic processes ensheathing many synapses. Despite significant progress made understanding contribution a few plasticity-related proteins have been identified so far. this study, we present evidence indicating role of astrocyte-secreted Lipocalin-2 (Lcn2) plasticity. We show Lcn2 expression is induced hippocampal astrocytes kainate-evoked aberrant plasticity model. Next, demonstrate chemically long-term potentiation (cLTP) similarly increases neuronal–glial co-cultures, glutamate causes immediate release these cultures. Additionally, through experiments primary cultures, reveal triggered by calcium signaling, brief treatment co-cultures with alters dendritic spines. Based findings, propose as an activity-dependent molecule released influences spine morphology.

Язык: Английский

Astrocyte-Secreted Lcn2 Modulates Dendritic Spine Morphology DOI Creative Commons
Marta Doliwa, Bożena Kuźniewska, Karolina Nader

и другие.

Cells, Год журнала: 2025, Номер 14(3), С. 159 - 159

Опубликована: Янв. 21, 2025

Learning and memory formation rely on synaptic plasticity, the process that changes strength in response to neuronal activity. In tripartite synapse concept, molecular signals affect morphology originate not only from pre- post-synaptic terminals but also astrocytic processes ensheathing many synapses. Despite significant progress made understanding contribution a few plasticity-related proteins have been identified so far. this study, we present evidence indicating role of astrocyte-secreted Lipocalin-2 (Lcn2) plasticity. We show Lcn2 expression is induced hippocampal astrocytes kainate-evoked aberrant plasticity model. Next, demonstrate chemically long-term potentiation (cLTP) similarly increases neuronal–glial co-cultures, glutamate causes immediate release these cultures. Additionally, through experiments primary cultures, reveal triggered by calcium signaling, brief treatment co-cultures with alters dendritic spines. Based findings, propose as an activity-dependent molecule released influences spine morphology.

Язык: Английский

Процитировано

0