Diffusion-based artificial genomes and their usefulness for local ancestry inference
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 31, 2024
Abstract
The
creation
of
synthetic
data
through
generative
modeling
has
emerged
as
a
significant
area
research
in
genomics,
offering
versatile
applications
from
tailoring
functional
sequences
with
specific
attributes
to
generating
high-quality,
privacy-preserving
silico
genomes.
Notwithstanding
these
advancements,
key
challenge
remains:
while
some
methods
exist
evaluate
artificially
generated
genomic
data,
comprehensive
tools
assess
its
usefulness
are
still
limited.
To
tackle
this
issue
and
present
promising
use
case,
we
test
artificial
genomes
within
the
framework
population
genetics
local
ancestry
inference
(LAI).
Building
on
previous
work
deep
for
introduce
novel,
frugal
diffusion
model
show
that
it
produces
high-quality
data.
We
then
performance
downstream
machine
learning
LAI
trained
composite
datasets
comprising
both
real
and/or
Our
findings
reveal
achieves
comparable
when
exclusively
versus
Moreover,
highlight
how
augmentation
using
significantly
benefits
model,
particularly
is
Finally,
compare
conventional
single
dataset
robust
ensemble
approach,
wherein
multiple
models
diverse
datasets,
their
predictions
aggregated.
study
highlights
potential
diffusion-based
integration
genomics.
This
approach
could
improve
fair
representation
across
populations
by
overcoming
accessibility
challenges,
ensuring
reliability
analyses
conducted
Язык: Английский
Embrace, Don’t Avoid: Reimagining Higher Education with Generative Artificial Intelligence
Journal of Educational Management and Learning,
Год журнала:
2024,
Номер
2(2), С. 81 - 90
Опубликована: Ноя. 28, 2024
This
paper
explores
the
potential
of
generative
artificial
intelligence
(AI)
to
transform
higher
education.
Generative
AI
is
a
technology
that
can
create
new
content,
like
text,
images,
and
code,
by
learning
patterns
from
existing
data.
As
tools
become
more
popular,
there
growing
interest
in
how
improve
teaching,
learning,
research.
Higher
education
faces
many
challenges,
such
as
meeting
diverse
needs
preparing
students
for
fast-changing
careers.
offers
solutions
personalizing
experiences,
making
engaging,
supporting
skill
development
through
adaptive
content.
It
also
help
researchers
automating
tasks
data
analysis
hypothesis
generation,
research
faster
efficient.
Moreover,
streamline
administrative
tasks,
improving
efficiency
across
institutions.
However,
using
raises
concerns
about
privacy,
bias,
academic
integrity,
equal
access.
To
address
these
issues,
institutions
must
establish
clear
ethical
guidelines,
ensure
security,
promote
fairness
use.
Training
faculty
literacy
are
essential
maximize
benefits
while
minimizing
risks.
The
suggests
strategic
framework
integrating
education,
focusing
on
infrastructure,
practices,
continuous
learning.
By
adopting
responsibly,
inclusive,
practical,
demands
technology-driven
world.
Язык: Английский