Energy Metabolism Supports Molecular and Functional Heterogeneity of Reactive Astrocytes in Central Nervous System Disorders
Medicinal Research Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
ABSTRACT
Astrocytes
undergo
a
reactive
transformation
in
central
nervous
system
(CNS)
disorders,
manifesting
significant
heterogeneity
morphology,
molecules,
function,
and
spatial
distribution.
Just
like
all
cells,
astrocytes
necessitate
energy
for
their
basic
functions.
Energy
production
proves
critical
the
survival
development
of
astrocytes,
as
well
fate
determination
functional
diversity.
The
activation
process
involves
metabolic
shift
energy,
yet
our
understanding
how
this
change
impacts
remains
limited.
In
comprehensive
review,
we
begin
by
outlining
advancements
research
on
CNS
establishing
crucial
association
between
metabolism
molecular
aspects.
Following
this,
delve
into
thorough
analysis
transitions
within
context
diseases.
Starting
from
essential
pathways
metabolism,
present
novel
perspective,
shedding
light
considering
metabolism.
conclusion,
propose
that
modulation
coupled
with
promotion
functionality
toward
disease
recovery,
represents
cutting‐edge
promising
strategy
treatment
Язык: Английский
Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
The
complex
set
of
interactions
between
the
immune
system
and
metabolism,
known
as
immunometabolism,
has
emerged
a
critical
regulator
disease
outcomes
in
central
nervous
system.
Numerous
studies
have
linked
metabolic
disturbances
to
impaired
responses
brain
aging,
neurodegenerative
disorders,
injury.
In
this
review,
we
will
discuss
how
disruptions
immunometabolism
balance
contribute
pathophysiology
dysfunction.
first
part
review
summarizes
contributions
cell
populations
such
microglia,
astrocytes,
infiltrating
cells
mediating
inflammation
metabolism
CNS
disorders.
remainder
addresses
impact
changes
on
activation
progression
Alzheimer's
disease,
Parkinson's
multiple
sclerosis,
stroke,
spinal
cord
injury,
traumatic
Furthermore,
also
address
therapeutic
potential
targeting
immunometabolic
pathways
reduce
neuroinflammation
slow
progression.
By
focusing
among
mechanisms
they
recruit
present
comprehensive
overview
human
health
disease.
Язык: Английский