Measles Virus Genotype A in Canada's Capital Region Wastewater Associated with Public Health Vaccination Initiatives DOI Creative Commons

Emma Tomalty,

Élisabeth Mercier, Lakshmi Pisharody

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 18, 2024

Abstract The recent global resurgence of measles in 2023-2024, despite its preventability through vaccination, is a significant public health concern largely driven by decreased vaccination coverage during the SARS-CoV-2 pandemic. To address this and to restore vaccine disrupted pandemic, Ottawa Public Health intensified efforts 2023 2024. Additionally, research initiative began April 2024 monitor wastewater for virus (MeV) using established environmental surveillance (WES) protocols. Given absence active cases region, unexpected positive MeV detections RT-qPCR prompted genotypic analysis as well retrospective archived RNA samples dating back 2020. identified detection belong genotype A, progenitor strain viral vaccines, marking first report shedding North American wastewater. Positive both real-time retrospectively analysed coincided with increased Health. These finding emphasize importance integrating into WES practices mitigate possible confounding factors, such highlights potential application monitoring community immunization real time. Implementing findings study WES, other re-emerging viruses, will enhance accuracy response optimize resource allocation.

Язык: Английский

Detection of Measles Virus Genotype A in a Non-Endemic Wastewater Setting: Insights from Measles Wastewater and Environmental Monitoring in Canada’s Capital Region DOI Creative Commons

Emma Tomalty,

Élisabeth Mercier, Lakshmi Pisharody

и другие.

Environmental Science & Technology Letters, Год журнала: 2025, Номер 12(2), С. 124 - 129

Опубликована: Фев. 2, 2025

The recent global resurgence of measles in 2023–2024, despite vaccine preventability, underscores a critical public health issue, largely due to reduced vaccination coverage during the SARS-CoV-2 pandemic. In response, Ottawa Public Health intensified efforts 2023 and 2024. Additionally, research initiative began April 2024 monitor wastewater for virus (MeV) using established environmental surveillance (WES) protocols. Unexpected positive MeV detections through RT-qPCR wastewater─despite no active regional cases─prompted genotypic retrospective analyses archived RNA samples dating back 2020. analysis identified detection belong genotype A, progenitor strain viral vaccines, marking first report large catchment area. Linear regression revealed aligned with by Health. These findings emphasize importance integrating into WES practices mitigate possible confounding factors, such as shedding wastewater. this highlights potential applications complementary tool. Implementing study WES, other re-emerging viruses, could improve response resource allocation.

Язык: Английский

Процитировано

0
Measles Virus Genotype A in Canada's Capital Region Wastewater Associated with Public Health Vaccination Initiatives DOI Creative Commons

Emma Tomalty,

Élisabeth Mercier, Lakshmi Pisharody

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 18, 2024

Abstract The recent global resurgence of measles in 2023-2024, despite its preventability through vaccination, is a significant public health concern largely driven by decreased vaccination coverage during the SARS-CoV-2 pandemic. To address this and to restore vaccine disrupted pandemic, Ottawa Public Health intensified efforts 2023 2024. Additionally, research initiative began April 2024 monitor wastewater for virus (MeV) using established environmental surveillance (WES) protocols. Given absence active cases region, unexpected positive MeV detections RT-qPCR prompted genotypic analysis as well retrospective archived RNA samples dating back 2020. identified detection belong genotype A, progenitor strain viral vaccines, marking first report shedding North American wastewater. Positive both real-time retrospectively analysed coincided with increased Health. These finding emphasize importance integrating into WES practices mitigate possible confounding factors, such highlights potential application monitoring community immunization real time. Implementing findings study WES, other re-emerging viruses, will enhance accuracy response optimize resource allocation.

Язык: Английский

Процитировано

0