A single cell and spatial genomics atlas of human skin fibroblasts in health and disease DOI Creative Commons
Lloyd Steele, Chloe Admane,

Keerthi Priya Chakala

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract Fibroblasts are critical cells that shape the architecture and cellular ecosystems in multiple tissues. Understanding fibroblast heterogeneity their spatial context health disease has enormous clinical relevance. In this study, we constructed a spatially-resolved atlas of human skin fibroblasts from healthy 23 disorders. We define 6 major populations further three disease-specific subtypes, demonstrate composition different types disease. characterise human-specific fibroblastic reticular cell (FRC)-like subtype perivascular niche postulate origin prenatal lymphoid tissue organiser (LTo)-like cells. also show inflammatory myofibroblasts ( IL11 + MMP1 CXCL5 IL7R+ ) conserved disorders cancers across provide harmonised nomenclature for integrates previous findings other

Язык: Английский

A single cell and spatial genomics atlas of human skin fibroblasts in health and disease DOI Creative Commons
Lloyd Steele, Chloe Admane,

Keerthi Priya Chakala

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract Fibroblasts are critical cells that shape the architecture and cellular ecosystems in multiple tissues. Understanding fibroblast heterogeneity their spatial context health disease has enormous clinical relevance. In this study, we constructed a spatially-resolved atlas of human skin fibroblasts from healthy 23 disorders. We define 6 major populations further three disease-specific subtypes, demonstrate composition different types disease. characterise human-specific fibroblastic reticular cell (FRC)-like subtype perivascular niche postulate origin prenatal lymphoid tissue organiser (LTo)-like cells. also show inflammatory myofibroblasts ( IL11 + MMP1 CXCL5 IL7R+ ) conserved disorders cancers across provide harmonised nomenclature for integrates previous findings other

Язык: Английский

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